from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0411c/glnH

LFCtreatmentdescriptionclass of inhibitor

-0.988

Amikacinug/mL Amikacintranslation

-1.087

Cap5-10ug/mL Capreomycintranslation

-1.278

Rox10-50 ug/mL Roxithromycintranslation

-0.770

SM2-5 ug/mL Streptomycintranslation

-2.767

Tet5-10 ug/mL Tetracyclinetranslation

-1.047

Rif0.2-5ug/mL Rifampicintranscription

-0.245

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.534

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.622

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.699

CPZ10-50 ug/mL Chlorpromazinerespiration

0.450

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.049

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.491

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.426

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.200

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.079

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.447

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.632

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.867

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.642

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

3.508

KCN5-20 ug/mL Potassium cyaniderespiration

0.500

NaN30.2-2 mM Sodium aziderespiration

-0.126

Nigericin50 uM Nigericinrespiration

0.602

TRC10-150 ug/mL Triclosanrespiration

1.042

TRZ10-25 ug/mL Thioridazinerespiration

-0.921

Valinomycin0.5-10 uM Valinomycinrespiration

-0.256

ZnSO42 mM ZnSO4respiration

0.093

menadione6-10 ug/mL Menadionerespiration

-0.331

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.468

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.458

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.166

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.745

NRP_1Non-replicating persistence stage 1dosRassociated

-0.524

Amp0.2mg/mL AmpicillincellWall

-0.380

Cephalexin20-100 ug/mL CephalexincellWall

0.717

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.616

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.428

EMB10-20 ug/mL EthambutolcellWall

0.708

Eta12-40 ug/mL EthionamidecellWall

0.292

INH0.2-0.4 ug/mL IsoniazidcellWall

0.734

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.753

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.823

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.497

BZA0.12 mg/mL BenzamidearomaticAmides

0.086

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.050

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.439

H2O24 mM hydrogen peroxideDNAdamaging

0.026

Levo10 ug/mL LevofloxacinDNAdamaging

-0.580

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.191

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.058

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.673

UVUV-irradiationDNAdamaging

-0.007

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.486

Antimycin12.5-50 ug/mL Antimycin A?

-0.285

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.175

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.208

PA_2110-50 ug/mL Antitubercular compound PA-21?

2.972

PA8240.2-2 ug/mL PA-824?

0.827

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.480

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.258

Verapamil50 uM Verapamil?

-0.082

mercaptoethanol2 mM 2-Mercaptoethanol?

0.097

methoxatin10-20 ug/mL Methoxatin?