TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0726c/-:

update plot	correlation	link to info on gene
Rv2948c/fadD22	(cc=0.5819)	info on Rv2948c/fadD22
Rv3116/moeB2	(cc=0.5155)	info on Rv3116/moeB2
Rv0822c/-	(cc=0.4806)	info on Rv0822c/-
Rv1593c/-	(cc=0.4764)	info on Rv1593c/-
Rv3145/nuoA	(cc=0.4722)	info on Rv3145/nuoA
Rv2430c/PPE41	(cc=0.4448)	info on Rv2430c/PPE41
Rv3787c/-	(cc=0.4412)	info on Rv3787c/-
Rv1558/-	(cc=0.439)	info on Rv1558/-
Rv3151/nuoG	(cc=0.4363)	info on Rv3151/nuoG
Rv1059/-	(cc=0.4326)	info on Rv1059/-

Correlation of Rv0726c/- with Rv1558/-

Normalized LFCs for Rv0726c/-:
(description and provenance of datasets)

	Rv0726c/-	Rv1558/-
Fe_supp_jason_reseq	-0.248	0.248
low_pH_jason_reseq	-0.494	-1.022
NO_jason_reseq	-0.648	0.058
B6_jason_reseq	0.22	0.883
MHCII_jason_reseq	0.199	1.104
Isoniazid02	0.1	-0.687
Rifampicin4	0.276	0.682
Ethambutol3	-0.088	-0.305
Meropenem3	0.419	1.242
Vancomycin16	0.024	-0.159
Rv2680_day32	-1.212	0.042
H37Rv_KO_MarP	0.209	0.144
hypoxia_3wks	0.522	-0.287
hypoxia_6wks	0.516	-0.507
glycerol	-0.717	-0.503
cholesterol	-0.377	-0.504
AJ	0.333	0.462
Bibs02	-0.421	0.487
Bibs02c	0.12	0.649
BL6	0.869	-0.091
BL6a	0.647	0.317
BXD01	0.736	-0.044
BXD010	0.61	0.523
BXD011	1.075	0.149
BXD03	-0.108	0.256
BXD04	0.794	0.326
BXD05	0.998	-0.067
BXD06	0.664	0.24
BXD07	0.573	0.107
BXD08	0.987	0.218
BXD09	0.326	0.189
CAST	1.016	0.023
CCcont	0.103	-0.421
DS01	0.515	0.645
DS02	0.644	0.501
DS04	1.15	0.479
DS0c	0.555	1.358
GP01	-0.006	0.343
GP02	0.847	0.554
GP0c	-0.494	-0.201
NOD	0.203	-0.436
NZO	-0.431	0.462
PWK	0.492	0.311
H37Rv_KO_CtpC	-0.351	0.312
H37Rv_KO_CtpD	1.462	0.568
H37Rv_KO_Rv1272	0.143	-1.188
H37Rv_KO_SugABC	0.467	-1.189
H37Rv_KO_MbtN	-0.522	0.35
Trans05	0.31	-0.949
macrophage_unactivated	0.0	0.098
IL1	-0.747	0.409
Rapamycin	-0.325	0.543
Tcell	0.463	0.186
GMCSF	0.343	0.399
IFNab	-0.432	-0.269
IFNg	-0.361	0.123
IFNg_GMCSF1	0.82	0.135
Rv1432_day32	-0.503	-0.623
Rv1565c_day32	-1.884	-3.116
secA2_input	-0.506	-0.122
delta_Rv3594	0.653	-0.099
delta_Rv3717	-0.272	-0.186
delta_Rv3811	0.916	-0.335
delta_Rv0954	0.845	0.647
PonA1	0.781	0.9
EccD1_KO	-0.556	-0.585
EspI_KO	0.231	0.348
PE35_KO	-0.298	0.292
PPE68_KO	-0.301	0.87
glycerol2	0.346	0.397
lignocerate	0.139	0.385
oleate	1.18	0.72
phosphatidylcholine	0.766	0.469
acetate	-0.63	-0.336
glucAc	-0.97	0.241
Rv0950ko	0.145	0.552
Rv1096ko	0.205	-0.181
Rv3684ko	-0.504	0.095
delta_otsA_trehalose	2.046	1.305