TB Genome Annotation Portal

Rv3151 (nuoG)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: NADH-quinone oxidoreductase subunit G
  • REFSEQ: NADH dehydrogenase subunit G
  • PATRIC: NADH-ubiquinone oxidoreductase chain G (EC 1.6.5.3)
  • TUBERCULIST: Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
  • NCBI: Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
  • updated information (H37Rv4):
    • gene name: nuoG
    • function:
    • reference:
• Type: Not Target
• Start: 3516746
• End: 3519166
• Operon:


• Trans-membrane region:
  
• Role: I.B.6.a - aerobic
• GO terms:
  • GO:0055114 - oxidation-reduction process (Uniprot)
  • GO:0051539 - 4 iron, 4 sulfur cluster binding (Uniprot)
  • GO:0051537 - 2 iron, 2 sulfur cluster binding (Uniprot)
  • GO:0051536 - iron-sulfur cluster binding (Uniprot)
  • GO:0048038 - quinone binding (Uniprot)
  • GO:0046872 - metal ion binding (Uniprot)
  • GO:0043546 - molybdopterin cofactor binding (Uniprot)
  • GO:0042773 - ATP synthesis coupled electron transport (Uniprot)
  • GO:0033668 - negative regulation by symbiont of host apoptotic process (Uniprot)
  • GO:0016651 - oxidoreductase activity, acting on NAD(P)H (Uniprot)
  • GO:0016491 - oxidoreductase activity (Uniprot)
  • GO:0016020 - membrane (Uniprot)
  • GO:0009405 - pathogenesis (Uniprot)
  • GO:0009055 - electron transfer activity (Uniprot)
  • GO:0008137 - NADH dehydrogenase (ubiquinone) activity (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005618 - cell wall (Uniprot)
  • GO:0003954 - NADH dehydrogenase activity (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • MK[c] + NADH[c] -> 4 H[c] + MKH2[c] + NAD[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  5LDX	46%	Bos taurus	Structure of mammalian respiratory Complex I, class3.
  5LDW	46%	Bos taurus	Structure of mammalian respiratory Complex I, class1
  5LC5	46%	Bos taurus	Structure of mammalian respiratory Complex I, class2
  6H8K	40%	Yarrowia lipolytica	Crystal structure of a variant (Q133C in PSST) of Yarrowia lipolytica complex I

• Links to additional information on nuoG:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = 0.727 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

VTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQIPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQ
HGVMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADE
PFESYFSGNTVQICPVGALTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFTYATQPDVITTPLIRDGG
DPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVGF
EPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLATGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARL
AWVPRRAGERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETLAALLVGGIEPADFADPDAVLAALDATGFVVSLEL
RHSTVTERADVVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQ
PEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIV
KIGAGS

Additional Information