TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0726c/-:

update plot	correlation	link to info on gene
Rv2948c/fadD22	(cc=0.5819)	info on Rv2948c/fadD22
Rv3116/moeB2	(cc=0.5155)	info on Rv3116/moeB2
Rv0822c/-	(cc=0.4806)	info on Rv0822c/-
Rv1593c/-	(cc=0.4764)	info on Rv1593c/-
Rv3145/nuoA	(cc=0.4722)	info on Rv3145/nuoA
Rv2430c/PPE41	(cc=0.4448)	info on Rv2430c/PPE41
Rv3787c/-	(cc=0.4412)	info on Rv3787c/-
Rv1558/-	(cc=0.439)	info on Rv1558/-
Rv3151/nuoG	(cc=0.4363)	info on Rv3151/nuoG
Rv1059/-	(cc=0.4326)	info on Rv1059/-

Correlation of Rv0726c/- with Rv2948c/fadD22

Normalized LFCs for Rv0726c/-:
(description and provenance of datasets)

	Rv0726c/-	Rv2948c/fadD22
Fe_supp_jason_reseq	-0.248	0.32
low_pH_jason_reseq	-0.494	-0.775
NO_jason_reseq	-0.648	-0.496
B6_jason_reseq	0.22	-0.193
MHCII_jason_reseq	0.199	-0.17
Isoniazid02	0.1	0.084
Rifampicin4	0.276	-0.301
Ethambutol3	-0.088	0.681
Meropenem3	0.419	-0.079
Vancomycin16	0.024	0.687
Rv2680_day32	-1.212	-0.943
H37Rv_KO_MarP	0.209	0.358
hypoxia_3wks	0.522	0.658
hypoxia_6wks	0.516	0.47
glycerol	-0.717	-0.728
cholesterol	-0.377	-0.354
AJ	0.333	-0.803
Bibs02	-0.421	-0.085
Bibs02c	0.12	0.346
BL6	0.869	0.039
BL6a	0.647	0.344
BXD01	0.736	0.062
BXD010	0.61	0.521
BXD011	1.075	0.856
BXD03	-0.108	0.629
BXD04	0.794	0.204
BXD05	0.998	0.386
BXD06	0.664	0.302
BXD07	0.573	0.521
BXD08	0.987	0.187
BXD09	0.326	0.377
CAST	1.016	-0.025
CCcont	0.103	-0.274
DS01	0.515	-0.041
DS02	0.644	-0.301
DS04	1.15	0.176
DS0c	0.555	-0.24
GP01	-0.006	0.215
GP02	0.847	0.356
GP0c	-0.494	-0.476
NOD	0.203	-0.223
NZO	-0.431	-0.67
PWK	0.492	-0.041
H37Rv_KO_CtpC	-0.351	0.495
H37Rv_KO_CtpD	1.462	0.356
H37Rv_KO_Rv1272	0.143	0.748
H37Rv_KO_SugABC	0.467	0.901
H37Rv_KO_MbtN	-0.522	0.323
Trans05	0.31	0.532
macrophage_unactivated	0.0	-0.035
IL1	-0.747	0.208
Rapamycin	-0.325	-0.117
Tcell	0.463	0.085
GMCSF	0.343	0.193
IFNab	-0.432	0.263
IFNg	-0.361	-0.011
IFNg_GMCSF1	0.82	0.503
Rv1432_day32	-0.503	-0.935
Rv1565c_day32	-1.884	-1.224
secA2_input	-0.506	-0.518
delta_Rv3594	0.653	0.05
delta_Rv3717	-0.272	0.101
delta_Rv3811	0.916	0.158
delta_Rv0954	0.845	0.13
PonA1	0.781	0.006
EccD1_KO	-0.556	-0.227
EspI_KO	0.231	0.245
PE35_KO	-0.298	0.178
PPE68_KO	-0.301	0.259
glycerol2	0.346	0.282
lignocerate	0.139	0.104
oleate	1.18	0.702
phosphatidylcholine	0.766	0.253
acetate	-0.63	-0.436
glucAc	-0.97	-0.557
Rv0950ko	0.145	0.335
Rv1096ko	0.205	-0.633
Rv3684ko	-0.504	-0.2
delta_otsA_trehalose	2.046	0.902