TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0647c/-:

update plot	correlation	link to info on gene
Rv0473/-	(cc=0.5503)	info on Rv0473/-
Rv0742/PE_PGRS8	(cc=0.5395)	info on Rv0742/PE_PGRS8
Rv1128c/-	(cc=0.5296)	info on Rv1128c/-
Rv1787/PPE25	(cc=0.5248)	info on Rv1787/PPE25
Rv0148/-	(cc=0.5141)	info on Rv0148/-
Rv3020c/esxS	(cc=0.5091)	info on Rv3020c/esxS
Rv2584c/apt	(cc=0.501)	info on Rv2584c/apt
Rv3840/-	(cc=0.4988)	info on Rv3840/-
Rv0844c/narL	(cc=0.4885)	info on Rv0844c/narL
Rv1622c/cydB	(cc=0.4879)	info on Rv1622c/cydB

Correlation of Rv0647c/- with Rv3840/-

Normalized LFCs for Rv0647c/-:
(description and provenance of datasets)

	Rv0647c/-	Rv3840/-
Fe_supp_jason_reseq	-0.965	-0.158
low_pH_jason_reseq	-0.893	-1.121
NO_jason_reseq	0.263	0.129
B6_jason_reseq	-0.411	-0.108
MHCII_jason_reseq	-1.082	-0.192
Isoniazid02	-0.678	-0.764
Rifampicin4	0.176	-0.374
Ethambutol3	-0.283	-0.652
Meropenem3	0.68	0.43
Vancomycin16	0.377	-0.584
Rv2680_day32	1.282	0.162
H37Rv_KO_MarP	0.083	0.182
hypoxia_3wks	0.594	0.191
hypoxia_6wks	0.593	0.311
glycerol	0.401	-0.032
cholesterol	-0.545	0.119
AJ	-0.57	0.21
Bibs02	0.789	0.123
Bibs02c	-0.45	-0.69
BL6	-0.232	0.27
BL6a	0.27	-0.059
BXD01	0.828	0.375
BXD010	-0.096	0.567
BXD011	1.056	0.188
BXD03	0.805	0.728
BXD04	0.494	0.453
BXD05	1.346	0.83
BXD06	1.106	0.55
BXD07	0.382	0.367
BXD08	2.15	0.353
BXD09	0.25	0.68
CAST	-0.174	0.402
CCcont	-0.977	-0.058
DS01	0.166	0.05
DS02	-0.468	0.537
DS04	0.424	0.233
DS0c	0.431	0.167
GP01	2.005	0.636
GP02	1.541	1.625
GP0c	1.998	0.811
NOD	-1.181	0.439
NZO	0.14	-0.095
PWK	0.75	0.323
H37Rv_KO_CtpC	-0.45	0.238
H37Rv_KO_CtpD	1.267	0.113
H37Rv_KO_Rv1272	0.586	0.542
H37Rv_KO_SugABC	-0.901	0.935
H37Rv_KO_MbtN	1.806	0.526
Trans05	0.665	-0.102
macrophage_unactivated	2.25	-0.076
IL1	0.955	-0.208
Rapamycin	1.182	0.47
Tcell	1.254	0.166
GMCSF	2.131	0.111
IFNab	0.774	0.49
IFNg	0.861	0.2
IFNg_GMCSF1	1.012	0.101
Rv1432_day32	1.669	0.349
Rv1565c_day32	0.359	0.039
secA2_input	0.606	0.377
delta_Rv3594	-1.41	-0.415
delta_Rv3717	-0.077	0.074
delta_Rv3811	-0.578	-0.164
delta_Rv0954	-1.143	-0.225
PonA1	-1.249	-0.421
EccD1_KO	-0.099	-0.431
EspI_KO	-0.536	-0.191
PE35_KO	-0.359	-0.537
PPE68_KO	-0.394	-0.576
glycerol2	-0.319	0.314
lignocerate	-0.229	-0.073
oleate	0.525	0.625
phosphatidylcholine	-0.319	0.108
acetate	0.223	-0.487
glucAc	-0.569	-0.564
Rv0950ko	-0.603	0.697
Rv1096ko	-0.793	0.0
Rv3684ko	-1.189	0.049
delta_otsA_trehalose	-2.372	-1.073