TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0580c/-:

update plot	correlation	link to info on gene
Rv3652/PE_PGRS60	(cc=0.5132)	info on Rv3652/PE_PGRS60
Rv3062/ligB	(cc=0.501)	info on Rv3062/ligB
Rv2651c/-	(cc=0.4842)	info on Rv2651c/-
Rv3242c/-	(cc=0.4741)	info on Rv3242c/-
Rv0869c/moaA2	(cc=0.4712)	info on Rv0869c/moaA2
Rv0347/-	(cc=0.4631)	info on Rv0347/-
Rv0234c/gabD1	(cc=0.4524)	info on Rv0234c/gabD1
Rv0275c/-	(cc=0.4504)	info on Rv0275c/-
Rv2924c/fpg	(cc=0.4386)	info on Rv2924c/fpg
Rv0435c/-	(cc=0.4378)	info on Rv0435c/-

Correlation of Rv0580c/- with Rv0347/-

Normalized LFCs for Rv0580c/-:
(description and provenance of datasets)

	Rv0580c/-	Rv0347/-
Fe_supp_jason_reseq	-1.179	-0.63
low_pH_jason_reseq	0.276	-1.29
NO_jason_reseq	0.331	0.129
B6_jason_reseq	0.837	1.434
MHCII_jason_reseq	-0.232	0.048
Isoniazid02	0.07	1.582
Rifampicin4	-0.374	-0.165
Ethambutol3	-0.168	1.39
Meropenem3	-0.144	-0.151
Vancomycin16	0.127	0.589
Rv2680_day32	1.147	0.0
H37Rv_KO_MarP	0.394	0.535
hypoxia_3wks	0.459	-0.255
hypoxia_6wks	0.317	0.251
glycerol	0.503	1.191
cholesterol	0.039	0.568
AJ	0.237	0.212
Bibs02	-0.775	0.717
Bibs02c	-1.488	-0.359
BL6	-0.505	1.056
BL6a	-0.88	-1.036
BXD01	-0.978	-0.751
BXD010	-0.707	-0.67
BXD011	-0.94	0.0
BXD03	-1.726	-1.115
BXD04	-0.452	-0.713
BXD05	-1.344	-0.776
BXD06	-0.579	-0.043
BXD07	-1.139	0.383
BXD08	-0.946	-0.696
BXD09	-0.776	-0.735
CAST	0.12	-0.15
CCcont	-1.366	-0.372
DS01	-0.527	-0.236
DS02	-1.079	1.282
DS04	-1.806	-0.062
DS0c	0.085	-0.456
GP01	-0.903	-0.031
GP02	-0.649	-0.527
GP0c	-0.45	-0.551
NOD	0.488	-1.061
NZO	0.026	0.737
PWK	0.236	-0.264
H37Rv_KO_CtpC	-0.233	-1.456
H37Rv_KO_CtpD	-1.333	-1.454
H37Rv_KO_Rv1272	-1.648	-1.759
H37Rv_KO_SugABC	-1.778	-1.137
H37Rv_KO_MbtN	-0.23	-1.089
Trans05	-1.928	-0.988
macrophage_unactivated	0.208	-1.016
IL1	0.308	-0.611
Rapamycin	-0.918	-0.632
Tcell	-1.137	-0.16
GMCSF	0.591	0.364
IFNab	0.2	0.142
IFNg	-0.46	0.0
IFNg_GMCSF1	-0.635	0.0
Rv1432_day32	0.507	0.0
Rv1565c_day32	1.216	1.579
secA2_input	1.193	0.606
delta_Rv3594	-1.081	0.788
delta_Rv3717	-1.258	-0.438
delta_Rv3811	-1.408	0.287
delta_Rv0954	-0.536	0.0
PonA1	-0.995	0.323
EccD1_KO	-0.977	-0.145
EspI_KO	-0.516	-0.53
PE35_KO	-0.668	-1.003
PPE68_KO	-0.528	-1.469
glycerol2	-0.083	-0.88
lignocerate	-0.766	-0.471
oleate	-0.112	-0.89
phosphatidylcholine	-0.168	-0.704
acetate	-0.901	-0.836
glucAc	-1.579	0.0
Rv0950ko	0.663	1.848
Rv1096ko	0.866	3.384
Rv3684ko	0.72	3.674
delta_otsA_trehalose	0.128	2.561