TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0523c/-:

update plot	correlation	link to info on gene
Rv0571c/-	(cc=0.5714)	info on Rv0571c/-
Rv1291c/-	(cc=0.553)	info on Rv1291c/-
Rv2766c/-	(cc=0.5213)	info on Rv2766c/-
Rv1192/-	(cc=0.5164)	info on Rv1192/-
Rv2920c/amt	(cc=0.5155)	info on Rv2920c/amt
Rv3607c/folB	(cc=0.5078)	info on Rv3607c/folB
Rv3395c/-	(cc=0.4927)	info on Rv3395c/-
Rv0569/-	(cc=0.4905)	info on Rv0569/-
Rv0899/ompA	(cc=0.4901)	info on Rv0899/ompA
Rv1075c/-	(cc=0.4884)	info on Rv1075c/-

Correlation of Rv0523c/- with Rv2920c/amt

Normalized LFCs for Rv0523c/-:
(description and provenance of datasets)

	Rv0523c/-	Rv2920c/amt
Fe_supp_jason_reseq	-0.737	0.45
low_pH_jason_reseq	-0.475	-0.564
NO_jason_reseq	0.249	0.748
B6_jason_reseq	0.596	0.818
MHCII_jason_reseq	1.125	1.689
Isoniazid02	0.204	0.036
Rifampicin4	0.271	0.0
Ethambutol3	0.491	0.19
Meropenem3	-0.151	-0.126
Vancomycin16	0.454	0.0
Rv2680_day32	0.057	-0.647
H37Rv_KO_MarP	0.229	0.133
hypoxia_3wks	-0.423	-0.044
hypoxia_6wks	0.094	-0.184
glycerol	-0.26	-0.532
cholesterol	-0.297	-0.347
AJ	-0.402	0.086
Bibs02	0.109	0.197
Bibs02c	0.444	0.153
BL6	-0.94	-0.86
BL6a	-0.189	-0.725
BXD01	0.264	-0.12
BXD010	-0.055	-0.379
BXD011	-0.781	-0.623
BXD03	0.309	-0.506
BXD04	0.274	0.662
BXD05	-0.477	-0.541
BXD06	0.149	-0.238
BXD07	-0.228	-1.003
BXD08	-0.323	-0.511
BXD09	-0.483	-0.744
CAST	0.194	-0.058
CCcont	-0.895	-0.686
DS01	0.616	-0.029
DS02	0.496	-0.323
DS04	-0.015	-0.45
DS0c	0.256	0.938
GP01	0.041	-0.051
GP02	-0.789	-0.961
GP0c	-0.481	-1.135
NOD	0.156	-0.028
NZO	-0.283	-0.282
PWK	0.674	-0.101
H37Rv_KO_CtpC	-1.086	-0.827
H37Rv_KO_CtpD	-0.982	-0.658
H37Rv_KO_Rv1272	-0.753	-0.017
H37Rv_KO_SugABC	-1.402	-0.611
H37Rv_KO_MbtN	-1.265	-0.994
Trans05	0.237	-1.179
macrophage_unactivated	-0.59	0.344
IL1	-0.816	-1.094
Rapamycin	-0.488	-0.755
Tcell	0.316	0.046
GMCSF	-0.42	-0.037
IFNab	-0.71	-1.521
IFNg	-0.957	-0.986
IFNg_GMCSF1	0.079	-1.046
Rv1432_day32	0.233	0.4
Rv1565c_day32	-1.567	0.425
secA2_input	0.086	-0.642
delta_Rv3594	0.948	0.425
delta_Rv3717	0.927	-0.069
delta_Rv3811	0.631	-0.138
delta_Rv0954	0.678	0.452
PonA1	0.0	-0.398
EccD1_KO	0.747	0.0
EspI_KO	0.242	-0.479
PE35_KO	-0.312	0.312
PPE68_KO	-0.026	-0.426
glycerol2	0.35	0.062
lignocerate	0.239	0.085
oleate	0.81	0.204
phosphatidylcholine	0.283	0.109
acetate	-0.17	-0.642
glucAc	-0.555	-0.363
Rv0950ko	-0.13	0.621
Rv1096ko	-0.024	-0.145
Rv3684ko	0.056	0.154
delta_otsA_trehalose	-0.739	-0.34