TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0500/proC:

update plot	correlation	link to info on gene
Rv2927c/-	(cc=0.5319)	info on Rv2927c/-
Rv0821c/phoY2	(cc=0.4574)	info on Rv0821c/phoY2
Rv2751/-	(cc=0.4485)	info on Rv2751/-
Rv3922c/-	(cc=0.4361)	info on Rv3922c/-
Rv2530c/vapC39	(cc=0.4292)	info on Rv2530c/vapC39
Rv1418/lprH	(cc=0.429)	info on Rv1418/lprH
Rv0364/-	(cc=0.4256)	info on Rv0364/-
Rv0926c/-	(cc=0.4228)	info on Rv0926c/-
Rv3841/bfrB	(cc=0.418)	info on Rv3841/bfrB
Rv1720c/vapC12	(cc=0.4063)	info on Rv1720c/vapC12

Correlation of Rv0500/proC with Rv0926c/-

Normalized LFCs for Rv0500/proC:
(description and provenance of datasets)

	Rv0500/proC	Rv0926c/-
Fe_supp_jason_reseq	-0.415	0.06
low_pH_jason_reseq	-0.44	0.519
NO_jason_reseq	0.583	0.05
B6_jason_reseq	-0.292	-0.357
MHCII_jason_reseq	-0.257	0.709
Isoniazid02	0.0	0.895
Rifampicin4	-0.341	0.761
Ethambutol3	-0.153	0.927
Meropenem3	0.497	0.022
Vancomycin16	-0.698	0.414
Rv2680_day32	0.0	-1.629
H37Rv_KO_MarP	0.553	0.12
hypoxia_3wks	-1.388	-0.104
hypoxia_6wks	-1.013	-1.303
glycerol	0.0	0.63
cholesterol	0.0	0.111
AJ	0.0	-0.629
Bibs02	0.0	-0.391
Bibs02c	0.0	-0.899
BL6	0.0	0.28
BL6a	0.973	0.274
BXD01	0.0	0.015
BXD010	0.543	0.814
BXD011	0.35	0.753
BXD03	0.907	0.79
BXD04	0.236	0.552
BXD05	0.975	0.443
BXD06	0.469	0.634
BXD07	0.851	0.638
BXD08	1.096	0.298
BXD09	1.753	0.414
CAST	0.0	0.474
CCcont	0.0	0.621
DS01	0.0	-0.224
DS02	0.0	-0.347
DS04	0.0	-0.388
DS0c	0.0	-0.493
GP01	0.0	-1.476
GP02	0.0	-0.641
GP0c	0.0	-0.451
NOD	0.0	-0.132
NZO	0.0	0.131
PWK	0.0	0.108
H37Rv_KO_CtpC	0.0	0.918
H37Rv_KO_CtpD	0.0	-0.015
H37Rv_KO_Rv1272	0.0	0.25
H37Rv_KO_SugABC	0.0	0.672
H37Rv_KO_MbtN	0.0	-0.657
Trans05	0.131	0.862
macrophage_unactivated	0.884	0.35
IL1	-0.658	0.353
Rapamycin	0.0	0.838
Tcell	-0.349	-0.088
GMCSF	0.0	1.278
IFNab	0.0	0.623
IFNg	1.376	1.243
IFNg_GMCSF1	1.386	1.81
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	-0.112
secA2_input	0.545	0.556
delta_Rv3594	0.211	0.359
delta_Rv3717	0.174	-0.272
delta_Rv3811	0.721	0.0
delta_Rv0954	0.627	0.457
PonA1	0.437	-0.431
EccD1_KO	-1.273	-0.724
EspI_KO	0.87	0.242
PE35_KO	-1.129	-0.403
PPE68_KO	-0.579	-0.442
glycerol2	-0.369	0.113
lignocerate	-0.32	-0.196
oleate	-0.373	-0.364
phosphatidylcholine	-0.368	-0.204
acetate	-0.437	-0.023
glucAc	-0.272	0.056
Rv0950ko	1.049	1.067
Rv1096ko	0.38	0.754
Rv3684ko	-0.452	0.684
delta_otsA_trehalose	-0.133	-0.311