TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0500/proC:

update plot	correlation	link to info on gene
Rv2927c/-	(cc=0.5319)	info on Rv2927c/-
Rv0821c/phoY2	(cc=0.4574)	info on Rv0821c/phoY2
Rv2751/-	(cc=0.4485)	info on Rv2751/-
Rv3922c/-	(cc=0.4361)	info on Rv3922c/-
Rv2530c/vapC39	(cc=0.4292)	info on Rv2530c/vapC39
Rv1418/lprH	(cc=0.429)	info on Rv1418/lprH
Rv0364/-	(cc=0.4256)	info on Rv0364/-
Rv0926c/-	(cc=0.4228)	info on Rv0926c/-
Rv3841/bfrB	(cc=0.418)	info on Rv3841/bfrB
Rv1720c/vapC12	(cc=0.4063)	info on Rv1720c/vapC12

Correlation of Rv0500/proC with Rv0364/-

Normalized LFCs for Rv0500/proC:
(description and provenance of datasets)

	Rv0500/proC	Rv0364/-
Fe_supp_jason_reseq	-0.415	0.227
low_pH_jason_reseq	-0.44	0.124
NO_jason_reseq	0.583	0.557
B6_jason_reseq	-0.292	-0.736
MHCII_jason_reseq	-0.257	-0.905
Isoniazid02	0.0	-0.097
Rifampicin4	-0.341	-0.374
Ethambutol3	-0.153	-0.793
Meropenem3	0.497	-0.165
Vancomycin16	-0.698	-0.562
Rv2680_day32	0.0	2.062
H37Rv_KO_MarP	0.553	-0.906
hypoxia_3wks	-1.388	-0.427
hypoxia_6wks	-1.013	0.106
glycerol	0.0	-0.136
cholesterol	0.0	0.0
AJ	0.0	0.146
Bibs02	0.0	0.927
Bibs02c	0.0	-1.028
BL6	0.0	0.53
BL6a	0.973	0.562
BXD01	0.0	0.856
BXD010	0.543	-0.278
BXD011	0.35	1.463
BXD03	0.907	0.84
BXD04	0.236	0.288
BXD05	0.975	1.018
BXD06	0.469	1.411
BXD07	0.851	0.861
BXD08	1.096	0.963
BXD09	1.753	1.417
CAST	0.0	-0.155
CCcont	0.0	1.35
DS01	0.0	-0.159
DS02	0.0	1.966
DS04	0.0	-0.583
DS0c	0.0	-0.85
GP01	0.0	0.777
GP02	0.0	-0.25
GP0c	0.0	0.369
NOD	0.0	1.699
NZO	0.0	-0.134
PWK	0.0	0.915
H37Rv_KO_CtpC	0.0	0.379
H37Rv_KO_CtpD	0.0	-0.496
H37Rv_KO_Rv1272	0.0	0.4
H37Rv_KO_SugABC	0.0	-0.298
H37Rv_KO_MbtN	0.0	0.959
Trans05	0.131	0.371
macrophage_unactivated	0.884	0.164
IL1	-0.658	-0.329
Rapamycin	0.0	0.316
Tcell	-0.349	1.352
GMCSF	0.0	-0.779
IFNab	0.0	0.311
IFNg	1.376	-0.617
IFNg_GMCSF1	1.386	2.316
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.545	0.283
delta_Rv3594	0.211	0.353
delta_Rv3717	0.174	1.446
delta_Rv3811	0.721	1.947
delta_Rv0954	0.627	0.886
PonA1	0.437	-0.95
EccD1_KO	-1.273	-1.441
EspI_KO	0.87	-1.383
PE35_KO	-1.129	-2.354
PPE68_KO	-0.579	-3.424
glycerol2	-0.369	-0.321
lignocerate	-0.32	-0.341
oleate	-0.373	-1.191
phosphatidylcholine	-0.368	-0.88
acetate	-0.437	-0.221
glucAc	-0.272	0.451
Rv0950ko	1.049	1.668
Rv1096ko	0.38	2.714
Rv3684ko	-0.452	2.021
delta_otsA_trehalose	-0.133	-0.861