TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0377/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv1638A/-	(cc=0.6094)	info on Rv1638A/-
Rv1291c/-	(cc=0.597)	info on Rv1291c/-
Rv3078/hab	(cc=0.5644)	info on Rv3078/hab
Rv0848/cysK2	(cc=0.5584)	info on Rv0848/cysK2
Rv2831/echA16	(cc=0.5527)	info on Rv2831/echA16
Rv0889c/citA	(cc=0.551)	info on Rv0889c/citA
Rv2725c/hflX	(cc=0.5417)	info on Rv2725c/hflX
Rv0914c/-	(cc=0.5359)	info on Rv0914c/-
Rv1287/-	(cc=0.5356)	info on Rv1287/-
Rv0039c/-	(cc=0.5349)	info on Rv0039c/-

Correlation of Rv0377/- with Rv1638A/-

Normalized LFCs for Rv0377/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv0377/-	Rv1638A/-
Fe_supp_jason_reseq	-0.655	0.74
low_pH_jason_reseq	-0.893	-0.192
NO_jason_reseq	1.189	0.415
B6_jason_reseq	0.636	0.982
MHCII_jason_reseq	0.217	0.893
Isoniazid02	0.451	0.0
Rifampicin4	0.368	-0.374
Ethambutol3	0.396	-0.168
Meropenem3	0.503	-0.165
Vancomycin16	0.26	-0.366
Rv2680_day32	-0.642	0.0
H37Rv_KO_MarP	0.746	-0.995
hypoxia_3wks	-0.694	0.08
hypoxia_6wks	-0.821	1.038
glycerol	-1.173	-0.199
cholesterol	0.323	-1.288
AJ	0.148	-1.708
Bibs02	1.06	0.473
Bibs02c	0.441	-1.694
BL6	-1.4	-1.608
BL6a	-0.346	-0.439
BXD01	-1.205	-1.055
BXD010	-0.352	-1.548
BXD011	-1.696	-0.64
BXD03	-1.01	0.062
BXD04	-0.584	-1.406
BXD05	-0.258	0.444
BXD06	-1.058	-0.296
BXD07	-1.844	-1.052
BXD08	-1.162	-0.032
BXD09	-0.713	-0.138
CAST	-0.766	-0.577
CCcont	-2.602	-1.597
DS01	0.541	-0.814
DS02	-0.098	-0.359
DS04	0.649	-0.216
DS0c	0.859	-0.418
GP01	-1.265	-2.256
GP02	-2.155	-1.901
GP0c	-2.122	-2.723
NOD	-0.205	-0.81
NZO	-1.29	-0.12
PWK	-0.342	-0.023
H37Rv_KO_CtpC	-1.392	-2.535
H37Rv_KO_CtpD	-1.364	-2.767
H37Rv_KO_Rv1272	-1.256	-1.216
H37Rv_KO_SugABC	0.456	0.812
H37Rv_KO_MbtN	-1.836	-2.355
Trans05	-2.179	-1.441
macrophage_unactivated	-0.36	0.17
IL1	0.789	0.264
Rapamycin	-1.522	-0.473
Tcell	-0.635	-0.775
GMCSF	-0.459	0.496
IFNab	-0.112	0.986
IFNg	-0.358	0.588
IFNg_GMCSF1	0.883	-1.247
Rv1432_day32	0.0	0.0
Rv1565c_day32	2.132	0.0
secA2_input	-0.861	0.598
delta_Rv3594	1.456	4.505
delta_Rv3717	0.452	2.81
delta_Rv3811	1.533	2.748
delta_Rv0954	1.591	1.553
PonA1	1.08	4.464
EccD1_KO	-0.171	0.194
EspI_KO	2.387	2.938
PE35_KO	1.552	0.796
PPE68_KO	0.688	-0.195
glycerol2	-2.626	-1.065
lignocerate	-1.671	-1.34
oleate	-0.784	0.15
phosphatidylcholine	-1.863	-1.199
acetate	-1.662	-0.622
glucAc	-2.542	-2.082
Rv0950ko	1.517	0.874
Rv1096ko	0.971	3.685
Rv3684ko	1.055	0.498
delta_otsA_trehalose	1.917	-0.468