TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0370c/-:

update plot	correlation	link to info on gene
Rv0827c/kmtR	(cc=0.5373)	info on Rv0827c/kmtR
Rv3291c/lrpA	(cc=0.5162)	info on Rv3291c/lrpA
Rv1891/-	(cc=0.4653)	info on Rv1891/-
Rv0845/-	(cc=0.4497)	info on Rv0845/-
Rv1397c/vapC10	(cc=0.4465)	info on Rv1397c/vapC10
Rv1662/pks8	(cc=0.4362)	info on Rv1662/pks8
Rv1507c/-	(cc=0.4336)	info on Rv1507c/-
Rv2793c/truB	(cc=0.4206)	info on Rv2793c/truB
Rv3904c/esxE	(cc=0.4159)	info on Rv3904c/esxE
Rv3023c/-	(cc=0.4149)	info on Rv3023c/-

Correlation of Rv0370c/- with Rv0845/-

Normalized LFCs for Rv0370c/-:
(description and provenance of datasets)

	Rv0370c/-	Rv0845/-
Fe_supp_jason_reseq	-0.553	-0.38
low_pH_jason_reseq	1.696	0.815
NO_jason_reseq	0.42	-0.41
B6_jason_reseq	-0.388	-0.712
MHCII_jason_reseq	-1.006	-1.227
Isoniazid02	-0.741	0.972
Rifampicin4	0.72	-0.081
Ethambutol3	-0.912	0.472
Meropenem3	-0.072	-0.097
Vancomycin16	0.101	0.204
Rv2680_day32	-0.893	-0.313
H37Rv_KO_MarP	-0.416	0.141
hypoxia_3wks	0.0	-0.088
hypoxia_6wks	0.372	-0.14
glycerol	0.471	-0.767
cholesterol	-0.098	-0.413
AJ	1.4	0.0
Bibs02	0.608	0.947
Bibs02c	-0.54	0.226
BL6	0.117	-0.073
BL6a	1.195	0.426
BXD01	0.042	0.572
BXD010	1.067	0.861
BXD011	1.169	0.568
BXD03	0.243	0.445
BXD04	0.382	0.457
BXD05	-0.188	-0.095
BXD06	0.73	0.223
BXD07	1.112	0.259
BXD08	0.442	0.392
BXD09	0.434	0.497
CAST	-0.237	0.537
CCcont	0.633	-0.035
DS01	0.075	0.349
DS02	-0.224	-0.347
DS04	-0.2	0.287
DS0c	-0.146	0.321
GP01	-0.594	-0.119
GP02	0.052	-1.034
GP0c	-0.86	-1.132
NOD	-0.775	0.376
NZO	1.631	1.046
PWK	0.789	0.192
H37Rv_KO_CtpC	1.305	0.713
H37Rv_KO_CtpD	1.835	0.797
H37Rv_KO_Rv1272	1.819	0.65
H37Rv_KO_SugABC	1.368	0.814
H37Rv_KO_MbtN	1.359	0.723
Trans05	1.569	1.127
macrophage_unactivated	0.518	1.026
IL1	0.985	0.531
Rapamycin	0.15	0.632
Tcell	-0.336	0.202
GMCSF	0.375	1.085
IFNab	-0.076	0.187
IFNg	0.78	0.732
IFNg_GMCSF1	-0.408	0.0
Rv1432_day32	0.524	0.407
Rv1565c_day32	0.82	0.379
secA2_input	-0.204	-0.369
delta_Rv3594	0.058	-0.174
delta_Rv3717	0.273	-0.656
delta_Rv3811	-0.757	0.171
delta_Rv0954	0.704	0.213
PonA1	1.062	-0.365
EccD1_KO	0.0	0.763
EspI_KO	0.736	0.63
PE35_KO	0.543	0.333
PPE68_KO	0.512	0.288
glycerol2	-0.618	0.025
lignocerate	-0.415	-0.15
oleate	-1.117	0.364
phosphatidylcholine	-0.618	0.025
acetate	0.658	-0.323
glucAc	0.184	-0.577
Rv0950ko	0.684	0.033
Rv1096ko	1.342	-0.133
Rv3684ko	0.829	0.141
delta_otsA_trehalose	-0.672	-0.421