TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0303/-:

update plot	correlation	link to info on gene
Rv0276/-	(cc=0.5835)	info on Rv0276/-
Rv0592/mce2D	(cc=0.5553)	info on Rv0592/mce2D
Rv3839/-	(cc=0.5345)	info on Rv3839/-
Rv0918/-	(cc=0.5206)	info on Rv0918/-
Rv2771c/-	(cc=0.5135)	info on Rv2771c/-
Rv0071/-	(cc=0.4974)	info on Rv0071/-
Rv3788/-	(cc=0.4881)	info on Rv3788/-
Rv3103c/-	(cc=0.4749)	info on Rv3103c/-
Rv1453/-	(cc=0.461)	info on Rv1453/-
Rv0233/nrdB	(cc=0.4576)	info on Rv0233/nrdB

Correlation of Rv0303/- with Rv3788/-

Normalized LFCs for Rv0303/-:
(description and provenance of datasets)

	Rv0303/-	Rv3788/-
Fe_supp_jason_reseq	0.071	-0.401
low_pH_jason_reseq	-0.577	-0.823
NO_jason_reseq	-0.494	-0.685
B6_jason_reseq	0.857	-1.016
MHCII_jason_reseq	-0.077	0.244
Isoniazid02	-0.162	0.227
Rifampicin4	-0.13	-0.439
Ethambutol3	-0.206	0.056
Meropenem3	-0.156	-0.158
Vancomycin16	-0.127	-1.451
Rv2680_day32	0.829	-0.326
H37Rv_KO_MarP	0.241	0.111
hypoxia_3wks	0.136	-0.259
hypoxia_6wks	0.66	-0.263
glycerol	-0.13	0.81
cholesterol	-0.764	0.463
AJ	-0.343	0.898
Bibs02	-0.65	0.069
Bibs02c	0.853	0.17
BL6	0.246	0.246
BL6a	0.098	-0.839
BXD01	-0.735	-0.732
BXD010	-0.357	-0.592
BXD011	-0.805	-0.781
BXD03	-0.487	-0.992
BXD04	-0.092	-0.7
BXD05	-0.316	-0.088
BXD06	-0.356	-0.275
BXD07	-0.369	-0.627
BXD08	-1.018	-0.877
BXD09	-0.325	-0.579
CAST	0.317	0.35
CCcont	-0.969	-0.215
DS01	-0.075	-0.051
DS02	0.325	0.573
DS04	0.24	-0.625
DS0c	0.239	-0.02
GP01	-0.658	-0.665
GP02	-1.356	-1.084
GP0c	-0.727	-0.608
NOD	0.436	1.378
NZO	-0.376	0.676
PWK	0.159	0.318
H37Rv_KO_CtpC	-0.116	0.737
H37Rv_KO_CtpD	0.669	0.672
H37Rv_KO_Rv1272	0.418	-1.091
H37Rv_KO_SugABC	-1.585	-2.448
H37Rv_KO_MbtN	-1.073	-0.968
Trans05	-0.511	-0.334
macrophage_unactivated	-0.177	-0.685
IL1	-0.092	-0.314
Rapamycin	-0.733	-0.126
Tcell	-0.287	-0.925
GMCSF	-0.301	-0.415
IFNab	-0.856	-0.381
IFNg	-0.083	0.0
IFNg_GMCSF1	-0.984	-0.952
Rv1432_day32	0.31	0.738
Rv1565c_day32	0.028	-0.472
secA2_input	0.554	1.594
delta_Rv3594	-0.58	-0.462
delta_Rv3717	-0.312	-0.344
delta_Rv3811	-0.739	-0.143
delta_Rv0954	-0.868	-0.836
PonA1	-0.119	0.507
EccD1_KO	-0.197	-0.888
EspI_KO	-0.836	-1.124
PE35_KO	-0.744	-0.613
PPE68_KO	-0.733	-1.357
glycerol2	-0.067	-0.2
lignocerate	-0.311	0.186
oleate	0.024	0.02
phosphatidylcholine	-0.126	0.253
acetate	-0.603	-0.575
glucAc	-0.315	-0.549
Rv0950ko	0.651	0.516
Rv1096ko	1.095	-0.241
Rv3684ko	0.956	-0.452
delta_otsA_trehalose	1.464	0.734