TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0287/esxG:

update plot	correlation	link to info on gene
Rv2392/cysH	(cc=0.5982)	info on Rv2392/cysH
Rv2445c/ndkA	(cc=0.5357)	info on Rv2445c/ndkA
Rv1298/rpmE	(cc=0.4819)	info on Rv1298/rpmE
Rv3265c/wbbL1	(cc=0.4606)	info on Rv3265c/wbbL1
Rv2507/-	(cc=0.4444)	info on Rv2507/-
Rv0504c/-	(cc=0.4328)	info on Rv0504c/-
Rv0841/-	(cc=0.4327)	info on Rv0841/-
Rv3212/-	(cc=0.4155)	info on Rv3212/-
Rv3649/-	(cc=0.3972)	info on Rv3649/-
Rv2087/-	(cc=0.3869)	info on Rv2087/-

Correlation of Rv0287/esxG with Rv3649/-

Normalized LFCs for Rv0287/esxG:
(description and provenance of datasets)

	Rv0287/esxG	Rv3649/-
Fe_supp_jason_reseq	1.897	0.332
low_pH_jason_reseq	0.0	-0.527
NO_jason_reseq	0.0	0.286
B6_jason_reseq	0.0	1.045
MHCII_jason_reseq	0.0	1.194
Isoniazid02	-0.383	0.469
Rifampicin4	0.872	1.243
Ethambutol3	0.27	1.043
Meropenem3	0.497	0.936
Vancomycin16	0.305	0.95
Rv2680_day32	0.0	-0.617
H37Rv_KO_MarP	-1.307	-0.731
hypoxia_3wks	0.0	0.223
hypoxia_6wks	0.0	0.077
glycerol	0.0	0.426
cholesterol	0.0	0.791
AJ	0.0	0.035
Bibs02	0.348	1.252
Bibs02c	0.0	0.621
BL6	0.0	0.773
BL6a	0.0	-0.032
BXD01	0.0	0.387
BXD010	0.0	0.588
BXD011	0.0	-0.082
BXD03	0.0	-0.204
BXD04	0.0	-0.039
BXD05	0.0	0.041
BXD06	0.0	0.041
BXD07	0.0	0.042
BXD08	0.0	-0.13
BXD09	0.0	-0.29
CAST	0.0	-0.265
CCcont	0.0	0.257
DS01	0.0	0.672
DS02	0.0	0.999
DS04	0.0	1.148
DS0c	0.0	0.767
GP01	0.188	-0.204
GP02	0.0	-0.386
GP0c	1.814	0.503
NOD	0.0	-0.107
NZO	0.0	-0.095
PWK	0.0	0.119
H37Rv_KO_CtpC	0.309	-1.203
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.0	0.146
H37Rv_KO_SugABC	0.0	0.117
H37Rv_KO_MbtN	0.0	0.42
Trans05	0.0	0.52
macrophage_unactivated	0.0	-0.537
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.13
GMCSF	0.0	0.401
IFNab	0.0	-0.06
IFNg	0.0	-0.337
IFNg_GMCSF1	0.0	0.305
Rv1432_day32	0.0	0.329
Rv1565c_day32	0.0	-0.463
secA2_input	-1.061	-0.049
delta_Rv3594	0.0	0.263
delta_Rv3717	1.165	1.061
delta_Rv3811	0.0	0.97
delta_Rv0954	0.756	0.249
PonA1	0.159	0.199
EccD1_KO	2.065	1.043
EspI_KO	-0.394	-0.148
PE35_KO	-0.403	0.487
PPE68_KO	1.113	0.314
glycerol2	0.0	-0.321
lignocerate	0.0	-0.363
oleate	0.0	-0.027
phosphatidylcholine	0.0	-0.258
acetate	0.0	-0.271
glucAc	0.0	0.726
Rv0950ko	0.416	0.443
Rv1096ko	2.045	1.212
Rv3684ko	0.861	0.704
delta_otsA_trehalose	0.0	-0.564