TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0287/esxG:

update plot	correlation	link to info on gene
Rv2392/cysH	(cc=0.5982)	info on Rv2392/cysH
Rv2445c/ndkA	(cc=0.5357)	info on Rv2445c/ndkA
Rv1298/rpmE	(cc=0.4819)	info on Rv1298/rpmE
Rv3265c/wbbL1	(cc=0.4606)	info on Rv3265c/wbbL1
Rv2507/-	(cc=0.4444)	info on Rv2507/-
Rv0504c/-	(cc=0.4328)	info on Rv0504c/-
Rv0841/-	(cc=0.4327)	info on Rv0841/-
Rv3212/-	(cc=0.4155)	info on Rv3212/-
Rv3649/-	(cc=0.3972)	info on Rv3649/-
Rv2087/-	(cc=0.3869)	info on Rv2087/-

Correlation of Rv0287/esxG with Rv2087/-

Normalized LFCs for Rv0287/esxG:
(description and provenance of datasets)

	Rv0287/esxG	Rv2087/-
Fe_supp_jason_reseq	1.897	2.344
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.383	0.089
Rifampicin4	0.872	1.289
Ethambutol3	0.27	2.23
Meropenem3	0.497	2.705
Vancomycin16	0.305	-0.17
Rv2680_day32	0.0	0.335
H37Rv_KO_MarP	-1.307	0.0
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	2.955
glycerol	0.0	-0.709
cholesterol	0.0	0.381
AJ	0.0	0.0
Bibs02	0.348	-0.642
Bibs02c	0.0	1.353
BL6	0.0	-0.439
BL6a	0.0	-0.696
BXD01	0.0	-0.458
BXD010	0.0	-0.45
BXD011	0.0	-0.448
BXD03	0.0	-0.475
BXD04	0.0	-0.434
BXD05	0.0	-0.339
BXD06	0.0	-0.469
BXD07	0.0	-0.486
BXD08	0.0	-0.467
BXD09	0.0	-0.494
CAST	0.0	0.0
CCcont	0.0	-0.24
DS01	0.0	-0.83
DS02	0.0	-0.764
DS04	0.0	-0.15
DS0c	0.0	-0.762
GP01	0.188	0.368
GP02	0.0	1.656
GP0c	1.814	1.835
NOD	0.0	2.151
NZO	0.0	-0.701
PWK	0.0	-0.494
H37Rv_KO_CtpC	0.309	-0.571
H37Rv_KO_CtpD	0.0	-0.098
H37Rv_KO_Rv1272	0.0	1.264
H37Rv_KO_SugABC	0.0	-0.159
H37Rv_KO_MbtN	0.0	1.968
Trans05	0.0	0.678
macrophage_unactivated	0.0	1.531
IL1	0.0	0.0
Rapamycin	0.0	2.081
Tcell	0.0	0.0
GMCSF	0.0	1.281
IFNab	0.0	0.417
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	1.838
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-1.061	-2.248
delta_Rv3594	0.0	0.684
delta_Rv3717	1.165	1.939
delta_Rv3811	0.0	1.228
delta_Rv0954	0.756	-0.375
PonA1	0.159	1.333
EccD1_KO	2.065	2.897
EspI_KO	-0.394	1.292
PE35_KO	-0.403	3.436
PPE68_KO	1.113	5.071
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	0.416	1.809
Rv1096ko	2.045	0.0
Rv3684ko	0.861	-0.832
delta_otsA_trehalose	0.0	0.382