TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0287/esxG:

update plot	correlation	link to info on gene
Rv2392/cysH	(cc=0.5982)	info on Rv2392/cysH
Rv2445c/ndkA	(cc=0.5357)	info on Rv2445c/ndkA
Rv1298/rpmE	(cc=0.4819)	info on Rv1298/rpmE
Rv3265c/wbbL1	(cc=0.4606)	info on Rv3265c/wbbL1
Rv2507/-	(cc=0.4444)	info on Rv2507/-
Rv0504c/-	(cc=0.4328)	info on Rv0504c/-
Rv0841/-	(cc=0.4327)	info on Rv0841/-
Rv3212/-	(cc=0.4155)	info on Rv3212/-
Rv3649/-	(cc=0.3972)	info on Rv3649/-
Rv2087/-	(cc=0.3869)	info on Rv2087/-

Correlation of Rv0287/esxG with Rv3265c/wbbL1

Normalized LFCs for Rv0287/esxG:
(description and provenance of datasets)

	Rv0287/esxG	Rv3265c/wbbL1
Fe_supp_jason_reseq	1.897	0.182
low_pH_jason_reseq	0.0	-0.44
NO_jason_reseq	0.0	-0.331
B6_jason_reseq	0.0	-0.292
MHCII_jason_reseq	0.0	-0.257
Isoniazid02	-0.383	0.0
Rifampicin4	0.872	0.374
Ethambutol3	0.27	0.32
Meropenem3	0.497	0.315
Vancomycin16	0.305	0.366
Rv2680_day32	0.0	-0.131
H37Rv_KO_MarP	-1.307	0.141
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.263
glycerol	0.0	0.265
cholesterol	0.0	0.0
AJ	0.0	-0.983
Bibs02	0.348	0.898
Bibs02c	0.0	-0.677
BL6	0.0	-0.53
BL6a	0.0	-0.462
BXD01	0.0	-0.422
BXD010	0.0	-0.543
BXD011	0.0	-0.412
BXD03	0.0	-0.315
BXD04	0.0	-0.524
BXD05	0.0	-0.57
BXD06	0.0	-0.566
BXD07	0.0	-0.587
BXD08	0.0	-0.564
BXD09	0.0	-0.596
CAST	0.0	-0.537
CCcont	0.0	-0.633
DS01	0.0	-0.765
DS02	0.0	0.285
DS04	0.0	-0.822
DS0c	0.0	-0.919
GP01	0.188	0.485
GP02	0.0	-0.194
GP0c	1.814	0.391
NOD	0.0	-0.524
NZO	0.0	-0.845
PWK	0.0	-0.831
H37Rv_KO_CtpC	0.309	0.213
H37Rv_KO_CtpD	0.0	1.425
H37Rv_KO_Rv1272	0.0	0.811
H37Rv_KO_SugABC	0.0	-0.42
H37Rv_KO_MbtN	0.0	-0.437
Trans05	0.0	-0.305
macrophage_unactivated	0.0	-0.83
IL1	0.0	-0.78
Rapamycin	0.0	-0.807
Tcell	0.0	-0.857
GMCSF	0.0	-0.694
IFNab	0.0	-0.795
IFNg	0.0	-0.703
IFNg_GMCSF1	0.0	-0.826
Rv1432_day32	0.0	-0.231
Rv1565c_day32	0.0	0.0
secA2_input	-1.061	0.18
delta_Rv3594	0.0	-0.635
delta_Rv3717	1.165	0.254
delta_Rv3811	0.0	-1.487
delta_Rv0954	0.756	-0.802
PonA1	0.159	-0.372
EccD1_KO	2.065	1.654
EspI_KO	-0.394	0.633
PE35_KO	-0.403	0.939
PPE68_KO	1.113	1.03
glycerol2	0.0	-0.758
lignocerate	0.0	-0.826
oleate	0.0	-0.425
phosphatidylcholine	0.0	-0.758
acetate	0.0	-1.127
glucAc	0.0	-0.701
Rv0950ko	0.416	0.347
Rv1096ko	2.045	1.999
Rv3684ko	0.861	0.727
delta_otsA_trehalose	0.0	0.111