TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0287/esxG:

update plot	correlation	link to info on gene
Rv2392/cysH	(cc=0.5982)	info on Rv2392/cysH
Rv2445c/ndkA	(cc=0.5357)	info on Rv2445c/ndkA
Rv1298/rpmE	(cc=0.4819)	info on Rv1298/rpmE
Rv3265c/wbbL1	(cc=0.4606)	info on Rv3265c/wbbL1
Rv2507/-	(cc=0.4444)	info on Rv2507/-
Rv0504c/-	(cc=0.4328)	info on Rv0504c/-
Rv0841/-	(cc=0.4327)	info on Rv0841/-
Rv3212/-	(cc=0.4155)	info on Rv3212/-
Rv3649/-	(cc=0.3972)	info on Rv3649/-
Rv2087/-	(cc=0.3869)	info on Rv2087/-

Correlation of Rv0287/esxG with Rv2392/cysH

Normalized LFCs for Rv0287/esxG:
(description and provenance of datasets)

	Rv0287/esxG	Rv2392/cysH
Fe_supp_jason_reseq	1.897	1.796
low_pH_jason_reseq	0.0	0.979
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.383	0.351
Rifampicin4	0.872	-0.374
Ethambutol3	0.27	0.0
Meropenem3	0.497	0.151
Vancomycin16	0.305	-0.366
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-1.307	-1.081
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.348	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.0	0.0
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	0.188	0.0
GP02	0.0	0.0
GP0c	1.814	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.309	0.0
H37Rv_KO_CtpD	0.0	0.241
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.103
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-1.061	-0.412
delta_Rv3594	0.0	0.211
delta_Rv3717	1.165	0.0
delta_Rv3811	0.0	0.0
delta_Rv0954	0.756	0.99
PonA1	0.159	0.979
EccD1_KO	2.065	0.378
EspI_KO	-0.394	-0.75
PE35_KO	-0.403	0.939
PPE68_KO	1.113	0.71
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	0.416	1.167
Rv1096ko	2.045	3.339
Rv3684ko	0.861	2.695
delta_otsA_trehalose	0.0	0.133