TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0197/-:

update plot	correlation	link to info on gene
Rv0975c/fadE13	(cc=0.5592)	info on Rv0975c/fadE13
Rv0456B/mazE1	(cc=0.5537)	info on Rv0456B/mazE1
Rv1501/-	(cc=0.5435)	info on Rv1501/-
Rv0160c/PE4	(cc=0.5377)	info on Rv0160c/PE4
Rv0148/-	(cc=0.5319)	info on Rv0148/-
Rv0145/-	(cc=0.5266)	info on Rv0145/-
Rv2004c/-	(cc=0.5216)	info on Rv2004c/-
Rv3045/adhC	(cc=0.5198)	info on Rv3045/adhC
Rv0073/-	(cc=0.5135)	info on Rv0073/-
Rv3023c/-	(cc=0.5012)	info on Rv3023c/-

Correlation of Rv0197/- with Rv3045/adhC

Normalized LFCs for Rv0197/-:
(description and provenance of datasets)

	Rv0197/-	Rv3045/adhC
Fe_supp_jason_reseq	-0.316	1.118
low_pH_jason_reseq	1.066	1.246
NO_jason_reseq	0.171	-1.987
B6_jason_reseq	-0.383	-0.069
MHCII_jason_reseq	-0.211	-0.36
Isoniazid02	-1.563	-2.177
Rifampicin4	0.241	-0.65
Ethambutol3	-0.905	-0.829
Meropenem3	-1.37	-2.737
Vancomycin16	-0.87	-2.43
Rv2680_day32	-0.026	0.379
H37Rv_KO_MarP	0.301	0.629
hypoxia_3wks	0.092	-4.115
hypoxia_6wks	-0.361	-2.023
glycerol	0.325	1.36
cholesterol	0.215	0.976
AJ	0.225	0.176
Bibs02	0.51	-0.189
Bibs02c	0.559	0.844
BL6	0.247	1.377
BL6a	0.439	0.904
BXD01	-0.077	1.168
BXD010	0.055	0.752
BXD011	0.477	1.184
BXD03	0.076	1.321
BXD04	0.702	1.514
BXD05	0.112	1.554
BXD06	-0.059	1.018
BXD07	-0.041	1.159
BXD08	0.538	1.052
BXD09	-0.042	1.65
CAST	0.537	0.454
CCcont	0.184	1.772
DS01	0.885	1.107
DS02	0.268	0.498
DS04	1.304	0.981
DS0c	0.699	1.07
GP01	0.147	-0.622
GP02	0.507	-0.726
GP0c	0.951	0.169
NOD	0.306	0.652
NZO	0.272	0.259
PWK	0.0	-0.161
H37Rv_KO_CtpC	0.688	0.612
H37Rv_KO_CtpD	1.121	1.994
H37Rv_KO_Rv1272	0.837	1.344
H37Rv_KO_SugABC	0.42	1.218
H37Rv_KO_MbtN	1.073	-0.107
Trans05	0.732	0.361
macrophage_unactivated	1.512	2.001
IL1	-0.552	-0.469
Rapamycin	0.261	0.832
Tcell	0.342	0.463
GMCSF	0.734	0.129
IFNab	0.317	0.629
IFNg	0.492	-0.497
IFNg_GMCSF1	-0.138	-0.079
Rv1432_day32	0.269	-1.061
Rv1565c_day32	0.905	0.81
secA2_input	-0.205	0.534
delta_Rv3594	-0.615	0.298
delta_Rv3717	-0.19	0.279
delta_Rv3811	-0.14	0.785
delta_Rv0954	-0.195	-0.125
PonA1	-0.331	0.172
EccD1_KO	0.194	0.217
EspI_KO	0.202	0.704
PE35_KO	-0.07	-0.242
PPE68_KO	-0.038	-0.176
glycerol2	-0.248	0.163
lignocerate	-0.552	0.688
oleate	-0.163	-0.106
phosphatidylcholine	-0.464	0.468
acetate	-0.329	-0.081
glucAc	-0.756	0.496
Rv0950ko	0.265	0.199
Rv1096ko	0.0	0.82
Rv3684ko	0.819	1.281
delta_otsA_trehalose	-0.922	-1.408