TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0197/-:

update plot	correlation	link to info on gene
Rv0975c/fadE13	(cc=0.5592)	info on Rv0975c/fadE13
Rv0456B/mazE1	(cc=0.5537)	info on Rv0456B/mazE1
Rv1501/-	(cc=0.5435)	info on Rv1501/-
Rv0160c/PE4	(cc=0.5377)	info on Rv0160c/PE4
Rv0148/-	(cc=0.5319)	info on Rv0148/-
Rv0145/-	(cc=0.5266)	info on Rv0145/-
Rv2004c/-	(cc=0.5216)	info on Rv2004c/-
Rv3045/adhC	(cc=0.5198)	info on Rv3045/adhC
Rv0073/-	(cc=0.5135)	info on Rv0073/-
Rv3023c/-	(cc=0.5012)	info on Rv3023c/-

Correlation of Rv0197/- with Rv0073/-

Normalized LFCs for Rv0197/-:
(description and provenance of datasets)

	Rv0197/-	Rv0073/-
Fe_supp_jason_reseq	-0.316	-0.133
low_pH_jason_reseq	1.066	-0.422
NO_jason_reseq	0.171	-0.761
B6_jason_reseq	-0.383	0.152
MHCII_jason_reseq	-0.211	-0.392
Isoniazid02	-1.563	-1.654
Rifampicin4	0.241	-0.801
Ethambutol3	-0.905	-0.55
Meropenem3	-1.37	-1.17
Vancomycin16	-0.87	-1.141
Rv2680_day32	-0.026	0.489
H37Rv_KO_MarP	0.301	0.0
hypoxia_3wks	0.092	-0.203
hypoxia_6wks	-0.361	-0.244
glycerol	0.325	0.812
cholesterol	0.215	0.242
AJ	0.225	-0.076
Bibs02	0.51	0.755
Bibs02c	0.559	0.915
BL6	0.247	0.766
BL6a	0.439	0.042
BXD01	-0.077	0.451
BXD010	0.055	0.271
BXD011	0.477	-0.245
BXD03	0.076	0.36
BXD04	0.702	0.559
BXD05	0.112	0.599
BXD06	-0.059	0.259
BXD07	-0.041	0.015
BXD08	0.538	-0.198
BXD09	-0.042	0.235
CAST	0.537	0.143
CCcont	0.184	-0.04
DS01	0.885	1.3
DS02	0.268	0.553
DS04	1.304	0.41
DS0c	0.699	0.903
GP01	0.147	0.275
GP02	0.507	0.285
GP0c	0.951	-0.336
NOD	0.306	0.395
NZO	0.272	0.306
PWK	0.0	0.796
H37Rv_KO_CtpC	0.688	0.467
H37Rv_KO_CtpD	1.121	1.33
H37Rv_KO_Rv1272	0.837	0.816
H37Rv_KO_SugABC	0.42	-0.049
H37Rv_KO_MbtN	1.073	-0.225
Trans05	0.732	1.018
macrophage_unactivated	1.512	0.208
IL1	-0.552	0.08
Rapamycin	0.261	0.338
Tcell	0.342	0.277
GMCSF	0.734	-0.256
IFNab	0.317	-0.187
IFNg	0.492	-0.241
IFNg_GMCSF1	-0.138	-0.512
Rv1432_day32	0.269	-0.489
Rv1565c_day32	0.905	-0.092
secA2_input	-0.205	0.269
delta_Rv3594	-0.615	-0.17
delta_Rv3717	-0.19	-0.341
delta_Rv3811	-0.14	-0.439
delta_Rv0954	-0.195	-0.134
PonA1	-0.331	-0.008
EccD1_KO	0.194	-0.102
EspI_KO	0.202	0.268
PE35_KO	-0.07	0.257
PPE68_KO	-0.038	0.531
glycerol2	-0.248	0.073
lignocerate	-0.552	-0.323
oleate	-0.163	0.336
phosphatidylcholine	-0.464	0.022
acetate	-0.329	-1.034
glucAc	-0.756	-0.98
Rv0950ko	0.265	0.271
Rv1096ko	0.0	0.305
Rv3684ko	0.819	-0.698
delta_otsA_trehalose	-0.922	-0.232