TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0197/-:

update plot	correlation	link to info on gene
Rv0975c/fadE13	(cc=0.5592)	info on Rv0975c/fadE13
Rv0456B/mazE1	(cc=0.5537)	info on Rv0456B/mazE1
Rv1501/-	(cc=0.5435)	info on Rv1501/-
Rv0160c/PE4	(cc=0.5377)	info on Rv0160c/PE4
Rv0148/-	(cc=0.5319)	info on Rv0148/-
Rv0145/-	(cc=0.5266)	info on Rv0145/-
Rv2004c/-	(cc=0.5216)	info on Rv2004c/-
Rv3045/adhC	(cc=0.5198)	info on Rv3045/adhC
Rv0073/-	(cc=0.5135)	info on Rv0073/-
Rv3023c/-	(cc=0.5012)	info on Rv3023c/-

Correlation of Rv0197/- with Rv1501/-

Normalized LFCs for Rv0197/-:
(description and provenance of datasets)

	Rv0197/-	Rv1501/-
Fe_supp_jason_reseq	-0.316	0.534
low_pH_jason_reseq	1.066	-0.284
NO_jason_reseq	0.171	0.0
B6_jason_reseq	-0.383	0.357
MHCII_jason_reseq	-0.211	1.169
Isoniazid02	-1.563	-1.711
Rifampicin4	0.241	0.523
Ethambutol3	-0.905	-2.135
Meropenem3	-1.37	-2.414
Vancomycin16	-0.87	-0.748
Rv2680_day32	-0.026	0.594
H37Rv_KO_MarP	0.301	-0.267
hypoxia_3wks	0.092	0.104
hypoxia_6wks	-0.361	0.457
glycerol	0.325	-0.11
cholesterol	0.215	-0.551
AJ	0.225	0.708
Bibs02	0.51	0.354
Bibs02c	0.559	0.553
BL6	0.247	-0.045
BL6a	0.439	-0.343
BXD01	-0.077	-0.095
BXD010	0.055	-0.222
BXD011	0.477	0.129
BXD03	0.076	0.549
BXD04	0.702	1.491
BXD05	0.112	0.797
BXD06	-0.059	0.07
BXD07	-0.041	-0.424
BXD08	0.538	0.963
BXD09	-0.042	0.465
CAST	0.537	0.732
CCcont	0.184	-0.493
DS01	0.885	0.842
DS02	0.268	-0.039
DS04	1.304	-0.419
DS0c	0.699	0.718
GP01	0.147	0.1
GP02	0.507	-0.618
GP0c	0.951	0.11
NOD	0.306	0.117
NZO	0.272	0.555
PWK	0.0	0.068
H37Rv_KO_CtpC	0.688	0.407
H37Rv_KO_CtpD	1.121	0.825
H37Rv_KO_Rv1272	0.837	0.655
H37Rv_KO_SugABC	0.42	1.084
H37Rv_KO_MbtN	1.073	1.254
Trans05	0.732	0.363
macrophage_unactivated	1.512	0.956
IL1	-0.552	-0.584
Rapamycin	0.261	-0.715
Tcell	0.342	0.652
GMCSF	0.734	-0.338
IFNab	0.317	-0.094
IFNg	0.492	-0.083
IFNg_GMCSF1	-0.138	-0.732
Rv1432_day32	0.269	0.188
Rv1565c_day32	0.905	0.535
secA2_input	-0.205	-0.302
delta_Rv3594	-0.615	-0.684
delta_Rv3717	-0.19	-1.104
delta_Rv3811	-0.14	-0.665
delta_Rv0954	-0.195	0.021
PonA1	-0.331	-1.191
EccD1_KO	0.194	-0.536
EspI_KO	0.202	-0.168
PE35_KO	-0.07	-0.537
PPE68_KO	-0.038	-0.253
glycerol2	-0.248	0.591
lignocerate	-0.552	0.247
oleate	-0.163	0.842
phosphatidylcholine	-0.464	0.591
acetate	-0.329	-0.14
glucAc	-0.756	-0.117
Rv0950ko	0.265	-0.235
Rv1096ko	0.0	-1.33
Rv3684ko	0.819	-0.992
delta_otsA_trehalose	-0.922	-2.691