TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0161/-:

update plot	correlation	link to info on gene
Rv1336/cysM	(cc=0.5952)	info on Rv1336/cysM
Rv3146/nuoB	(cc=0.5612)	info on Rv3146/nuoB
Rv3150/nuoF	(cc=0.5603)	info on Rv3150/nuoF
Rv1980c/mpt64	(cc=0.5438)	info on Rv1980c/mpt64
Rv1105/-	(cc=0.5405)	info on Rv1105/-
Rv0170/mce1B	(cc=0.5389)	info on Rv0170/mce1B
Rv2350c/plcB	(cc=0.5269)	info on Rv2350c/plcB
Rv3152/nuoH	(cc=0.5195)	info on Rv3152/nuoH
Rv2243/fabD	(cc=0.516)	info on Rv2243/fabD
Rv3151/nuoG	(cc=0.5114)	info on Rv3151/nuoG

Correlation of Rv0161/- with Rv2350c/plcB

Normalized LFCs for Rv0161/-:
(description and provenance of datasets)

	Rv0161/-	Rv2350c/plcB
Fe_supp_jason_reseq	-0.933	0.153
low_pH_jason_reseq	-1.226	-0.32
NO_jason_reseq	0.173	-0.116
B6_jason_reseq	-0.512	-0.249
MHCII_jason_reseq	-0.645	-0.936
Isoniazid02	0.208	-0.953
Rifampicin4	0.43	-0.022
Ethambutol3	-0.118	0.525
Meropenem3	0.211	-0.677
Vancomycin16	0.682	-0.501
Rv2680_day32	1.308	0.171
H37Rv_KO_MarP	-0.023	0.286
hypoxia_3wks	1.228	2.285
hypoxia_6wks	1.865	2.076
glycerol	-1.172	-0.12
cholesterol	0.027	0.923
AJ	-0.728	0.445
Bibs02	-0.348	0.579
Bibs02c	0.194	-0.38
BL6	0.639	0.747
BL6a	1.012	0.951
BXD01	0.769	0.845
BXD010	0.798	1.313
BXD011	0.588	0.691
BXD03	0.674	1.102
BXD04	1.686	1.076
BXD05	0.671	1.051
BXD06	0.458	0.598
BXD07	0.802	0.931
BXD08	1.42	0.805
BXD09	0.89	0.694
CAST	-1.044	0.098
CCcont	0.763	0.588
DS01	-0.092	-0.31
DS02	-0.315	-0.739
DS04	-0.415	0.736
DS0c	-0.363	-0.376
GP01	-0.143	0.581
GP02	-0.121	-0.13
GP0c	0.517	0.257
NOD	0.168	1.66
NZO	0.685	0.153
PWK	0.182	0.364
H37Rv_KO_CtpC	0.848	0.853
H37Rv_KO_CtpD	0.816	1.379
H37Rv_KO_Rv1272	1.425	0.921
H37Rv_KO_SugABC	-1.398	0.438
H37Rv_KO_MbtN	-0.407	0.495
Trans05	1.704	1.562
macrophage_unactivated	-0.65	0.041
IL1	-0.854	0.454
Rapamycin	-0.396	0.021
Tcell	-0.182	0.596
GMCSF	-0.673	-0.09
IFNab	-0.212	-0.103
IFNg	-0.037	0.358
IFNg_GMCSF1	-0.647	0.041
Rv1432_day32	-0.164	0.576
Rv1565c_day32	-0.938	-0.115
secA2_input	-1.047	0.102
delta_Rv3594	-0.307	0.225
delta_Rv3717	-0.112	0.104
delta_Rv3811	0.427	0.677
delta_Rv0954	0.143	0.107
PonA1	-0.547	0.053
EccD1_KO	0.243	-0.408
EspI_KO	0.565	-0.317
PE35_KO	-0.181	-0.458
PPE68_KO	0.048	-0.355
glycerol2	0.247	0.465
lignocerate	-0.867	0.057
oleate	0.472	0.435
phosphatidylcholine	-0.282	0.29
acetate	-0.161	-0.186
glucAc	-0.143	-0.038
Rv0950ko	0.0	0.371
Rv1096ko	0.917	-0.467
Rv3684ko	0.802	0.386
delta_otsA_trehalose	-0.413	0.081