TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3753c/-:

update plot	correlation	link to info on gene
Rv3673c/-	(cc=0.8014)	info on Rv3673c/-
Rv2678c/hemE	(cc=0.7829)	info on Rv2678c/hemE
Rv3858c/gltD	(cc=0.6941)	info on Rv3858c/gltD
Rv3670/ephE	(cc=0.6718)	info on Rv3670/ephE
Rv0701/rplC	(cc=0.6627)	info on Rv0701/rplC
Rv3489/-	(cc=0.6376)	info on Rv3489/-
Rv2373c/dnaJ2	(cc=0.6353)	info on Rv2373c/dnaJ2
Rv2882c/frr	(cc=0.6341)	info on Rv2882c/frr
Rv0541c/-	(cc=0.6084)	info on Rv0541c/-
Rv2611c/-	(cc=0.6051)	info on Rv2611c/-

Correlation of Rv3753c/- with Rv3489/-

Normalized LFCs for Rv3753c/-:
(description and provenance of datasets)

	Rv3753c/-	Rv3489/-
Fe_supp_jason_reseq	1.778	0.415
low_pH_jason_reseq	0.582	0.0
NO_jason_reseq	-0.362	0.0
B6_jason_reseq	-0.153	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	-0.551
Rifampicin4	0.0	1.481
Ethambutol3	0.0	0.251
Meropenem3	0.0	-0.138
Vancomycin16	0.0	1.451
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.255	0.0
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.377
BXD01	0.0	0.0
BXD010	0.0	0.244
BXD011	0.243	0.0
BXD03	0.0	0.0
BXD04	1.619	0.0
BXD05	0.0	0.369
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.0	0.633
DS01	0.0	0.0
DS02	0.0	0.217
DS04	0.0	0.37
DS0c	0.0	0.413
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.162
H37Rv_KO_CtpD	0.127	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.189
H37Rv_KO_MbtN	0.0	0.103
Trans05	0.0	0.0
macrophage_unactivated	-0.436	0.0
IL1	-0.409	0.0
Rapamycin	-0.424	0.0
Tcell	-0.45	0.0
GMCSF	-0.364	0.0
IFNab	0.729	0.0
IFNg	0.644	0.0
IFNg_GMCSF1	-0.434	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	-0.766	0.415
secA2_input	-0.216	-1.868
delta_Rv3594	-0.369	-0.193
delta_Rv3717	0.955	-0.331
delta_Rv3811	0.697	0.0
delta_Rv0954	-0.149	0.0
PonA1	-0.278	-0.304
EccD1_KO	-3.667	-4.285
EspI_KO	-2.264	-2.966
PE35_KO	-2.917	-3.034
PPE68_KO	-1.213	-3.868
glycerol2	0.0	-2.081
lignocerate	0.0	-1.808
oleate	0.0	-2.105
phosphatidylcholine	0.0	-2.08
acetate	0.0	-0.472
glucAc	0.0	-1.535
Rv0950ko	0.0	-0.621
Rv1096ko	0.0	0.0
Rv3684ko	1.14	0.305
delta_otsA_trehalose	0.0	-1.193