TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3744/nmtR:

update plot	correlation	link to info on gene
Rv0393/-	(cc=0.4691)	info on Rv0393/-
Rv0133/-	(cc=0.4681)	info on Rv0133/-
Rv3470c/ilvB2	(cc=0.4677)	info on Rv3470c/ilvB2
Rv3558/PPE64	(cc=0.4654)	info on Rv3558/PPE64
Rv3142c/-	(cc=0.4531)	info on Rv3142c/-
Rv3517/-	(cc=0.4522)	info on Rv3517/-
Rv0823c/-	(cc=0.4468)	info on Rv0823c/-
Rv3912/-	(cc=0.4437)	info on Rv3912/-
Rv2797c/-	(cc=0.4368)	info on Rv2797c/-
Rv3904c/esxE	(cc=0.4334)	info on Rv3904c/esxE

Correlation of Rv3744/nmtR with Rv0393/-

Normalized LFCs for Rv3744/nmtR:
(description and provenance of datasets)

	Rv3744/nmtR	Rv0393/-
Fe_supp_jason_reseq	-1.793	-0.822
low_pH_jason_reseq	-0.982	0.042
NO_jason_reseq	0.134	-0.79
B6_jason_reseq	-1.443	0.352
MHCII_jason_reseq	-0.96	-0.898
Isoniazid02	0.23	-0.109
Rifampicin4	0.111	0.555
Ethambutol3	0.745	0.427
Meropenem3	0.298	0.975
Vancomycin16	0.162	-0.082
Rv2680_day32	-1.045	-0.373
H37Rv_KO_MarP	0.138	0.689
hypoxia_3wks	0.949	-0.459
hypoxia_6wks	-0.831	-1.052
glycerol	-0.025	0.638
cholesterol	0.079	0.513
AJ	1.198	0.903
Bibs02	-0.703	0.691
Bibs02c	-0.443	0.268
BL6	0.81	0.399
BL6a	-0.317	0.0
BXD01	0.426	0.447
BXD010	-0.481	0.207
BXD011	-0.149	-0.842
BXD03	-0.042	-0.639
BXD04	0.022	0.133
BXD05	0.049	0.265
BXD06	-0.377	-0.274
BXD07	0.301	0.062
BXD08	0.499	1.08
BXD09	-0.017	-0.164
CAST	0.429	1.356
CCcont	-0.186	0.028
DS01	-0.744	0.216
DS02	0.118	0.548
DS04	0.15	0.419
DS0c	0.278	0.242
GP01	0.809	0.394
GP02	0.245	-0.159
GP0c	-0.1	0.114
NOD	0.804	-0.018
NZO	0.643	0.838
PWK	1.65	1.395
H37Rv_KO_CtpC	1.471	0.34
H37Rv_KO_CtpD	1.334	-0.469
H37Rv_KO_Rv1272	-0.053	-0.152
H37Rv_KO_SugABC	1.483	0.959
H37Rv_KO_MbtN	-0.806	0.132
Trans05	0.485	0.539
macrophage_unactivated	-0.354	-0.685
IL1	-1.605	-0.276
Rapamycin	-0.921	0.049
Tcell	-0.661	0.121
GMCSF	-0.734	-0.399
IFNab	-1.218	-1.046
IFNg	-1.013	-0.871
IFNg_GMCSF1	-0.028	-0.311
Rv1432_day32	-1.276	0.046
Rv1565c_day32	-0.174	-1.264
secA2_input	1.747	1.14
delta_Rv3594	-0.424	0.017
delta_Rv3717	-0.245	0.042
delta_Rv3811	0.77	-0.21
delta_Rv0954	-0.074	0.106
PonA1	1.046	0.38
EccD1_KO	-0.375	0.145
EspI_KO	-0.95	-0.459
PE35_KO	-1.342	-0.298
PPE68_KO	-2.166	-0.413
glycerol2	-0.34	0.532
lignocerate	-0.801	0.795
oleate	0.751	0.275
phosphatidylcholine	-0.34	0.868
acetate	-0.316	-0.042
glucAc	-0.992	0.332
Rv0950ko	1.182	0.516
Rv1096ko	0.513	1.258
Rv3684ko	0.069	0.193
delta_otsA_trehalose	1.21	-0.147