TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3505/fadE27:

update plot	correlation	link to info on gene
Rv3152/nuoH	(cc=0.4212)	info on Rv3152/nuoH
Rv0755A/-	(cc=0.4163)	info on Rv0755A/-
Rv1362c/-	(cc=0.4051)	info on Rv1362c/-
Rv3382c/lytB1	(cc=0.3987)	info on Rv3382c/lytB1
Rv0052/-	(cc=0.3866)	info on Rv0052/-
Rv1021/-	(cc=0.3832)	info on Rv1021/-
Rv0799c/-	(cc=0.3697)	info on Rv0799c/-
Rv0459/-	(cc=0.3641)	info on Rv0459/-
Rv2548/vapC19	(cc=0.364)	info on Rv2548/vapC19
Rv3150/nuoF	(cc=0.3634)	info on Rv3150/nuoF

Correlation of Rv3505/fadE27 with Rv0052/-

Normalized LFCs for Rv3505/fadE27:
(description and provenance of datasets)

	Rv3505/fadE27	Rv0052/-
Fe_supp_jason_reseq	-0.939	0.502
low_pH_jason_reseq	-0.661	-0.336
NO_jason_reseq	0.898	0.643
B6_jason_reseq	-0.468	0.186
MHCII_jason_reseq	0.885	0.319
Isoniazid02	0.383	-0.425
Rifampicin4	-0.149	-0.766
Ethambutol3	-0.235	0.589
Meropenem3	-0.386	-0.629
Vancomycin16	0.321	-0.223
Rv2680_day32	-1.293	-1.275
H37Rv_KO_MarP	-0.188	1.122
hypoxia_3wks	0.538	0.116
hypoxia_6wks	0.192	0.244
glycerol	-0.762	0.6
cholesterol	-0.835	-0.04
AJ	0.108	0.03
Bibs02	1.094	0.836
Bibs02c	1.325	0.202
BL6	0.3	0.62
BL6a	1.403	1.126
BXD01	-0.552	0.97
BXD010	0.444	1.161
BXD011	0.631	1.033
BXD03	-0.421	1.143
BXD04	1.208	0.56
BXD05	0.042	1.25
BXD06	0.607	1.112
BXD07	0.4	0.882
BXD08	0.352	1.05
BXD09	0.208	1.046
CAST	-0.354	-0.21
CCcont	0.432	1.235
DS01	0.737	0.503
DS02	-1.027	0.378
DS04	0.465	1.886
DS0c	0.068	-0.58
GP01	-1.134	-0.669
GP02	0.379	-0.84
GP0c	-0.521	-0.738
NOD	-0.848	0.724
NZO	0.503	-0.124
PWK	-1.131	0.418
H37Rv_KO_CtpC	0.671	-0.161
H37Rv_KO_CtpD	1.244	1.366
H37Rv_KO_Rv1272	-0.501	0.807
H37Rv_KO_SugABC	0.575	0.763
H37Rv_KO_MbtN	0.078	0.048
Trans05	1.521	1.464
macrophage_unactivated	-1.086	-0.161
IL1	0.258	0.667
Rapamycin	0.448	1.139
Tcell	-0.815	0.87
GMCSF	1.325	0.457
IFNab	-0.079	0.831
IFNg	-0.668	0.812
IFNg_GMCSF1	-0.163	0.707
Rv1432_day32	-0.42	0.51
Rv1565c_day32	0.556	0.0
secA2_input	0.723	0.426
delta_Rv3594	-0.607	0.099
delta_Rv3717	-1.029	-0.695
delta_Rv3811	-0.674	-0.498
delta_Rv0954	-0.995	0.009
PonA1	-0.355	0.262
EccD1_KO	-0.51	-0.243
EspI_KO	-1.101	-0.573
PE35_KO	-0.131	-0.193
PPE68_KO	0.362	0.269
glycerol2	-0.324	0.28
lignocerate	-0.066	-0.013
oleate	0.0	0.132
phosphatidylcholine	-0.238	0.081
acetate	0.213	-0.214
glucAc	0.49	-0.011
Rv0950ko	-0.829	0.488
Rv1096ko	-0.274	1.173
Rv3684ko	-1.019	-0.291
delta_otsA_trehalose	0.422	-0.16