TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3370c/dnaE2:

update plot	correlation	link to info on gene
Rv1065/-	(cc=0.5386)	info on Rv1065/-
Rv3585/radA	(cc=0.5088)	info on Rv3585/radA
Rv1290c/-	(cc=0.4867)	info on Rv1290c/-
Rv0976c/-	(cc=0.4842)	info on Rv0976c/-
Rv1791/PE19	(cc=0.4656)	info on Rv1791/PE19
Rv3866/espG1	(cc=0.4499)	info on Rv3866/espG1
Rv3174/-	(cc=0.4466)	info on Rv3174/-
Rv0532/PE_PGRS6	(cc=0.4446)	info on Rv0532/PE_PGRS6
Rv1785c/cyp143	(cc=0.4438)	info on Rv1785c/cyp143
Rv0869c/moaA2	(cc=0.4386)	info on Rv0869c/moaA2

Correlation of Rv3370c/dnaE2 with Rv3174/-

Normalized LFCs for Rv3370c/dnaE2:
(description and provenance of datasets)

	Rv3370c/dnaE2	Rv3174/-
Fe_supp_jason_reseq	-0.33	0.159
low_pH_jason_reseq	0.353	0.99
NO_jason_reseq	0.042	-1.454
B6_jason_reseq	-0.83	-0.145
MHCII_jason_reseq	0.062	0.243
Isoniazid02	1.292	4.617
Rifampicin4	0.441	0.49
Ethambutol3	2.253	4.904
Meropenem3	1.745	-0.151
Vancomycin16	0.276	0.125
Rv2680_day32	-0.442	0.063
H37Rv_KO_MarP	0.721	0.317
hypoxia_3wks	-0.299	0.833
hypoxia_6wks	-0.731	0.921
glycerol	0.6	0.083
cholesterol	0.322	-0.534
AJ	0.328	-0.676
Bibs02	-0.517	0.331
Bibs02c	-0.211	0.906
BL6	0.25	1.413
BL6a	-0.112	1.167
BXD01	0.168	1.092
BXD010	0.313	1.144
BXD011	-0.383	0.44
BXD03	0.315	0.323
BXD04	0.302	0.592
BXD05	0.442	0.726
BXD06	-0.24	0.786
BXD07	-0.038	0.953
BXD08	-0.018	1.063
BXD09	0.181	1.187
CAST	0.325	0.157
CCcont	0.119	0.633
DS01	-0.625	-0.358
DS02	0.145	-0.095
DS04	0.027	0.233
DS0c	-0.574	-0.844
GP01	0.585	1.235
GP02	0.426	0.463
GP0c	0.598	1.627
NOD	-0.194	0.093
NZO	0.42	-0.087
PWK	-0.519	-0.028
H37Rv_KO_CtpC	0.581	-0.845
H37Rv_KO_CtpD	0.267	1.342
H37Rv_KO_Rv1272	0.344	0.636
H37Rv_KO_SugABC	0.231	-1.523
H37Rv_KO_MbtN	-0.136	-0.69
Trans05	0.416	-0.096
macrophage_unactivated	0.0	0.514
IL1	-0.151	0.116
Rapamycin	0.049	0.39
Tcell	0.052	0.971
GMCSF	1.03	0.552
IFNab	-0.154	-0.082
IFNg	-0.275	0.371
IFNg_GMCSF1	0.852	0.764
Rv1432_day32	0.038	0.3
Rv1565c_day32	-0.371	0.0
secA2_input	0.207	0.953
delta_Rv3594	0.211	-0.679
delta_Rv3717	-0.023	-0.559
delta_Rv3811	0.3	-0.416
delta_Rv0954	0.156	0.018
PonA1	0.196	-0.227
EccD1_KO	0.214	-0.477
EspI_KO	-0.145	-0.365
PE35_KO	0.327	0.0
PPE68_KO	0.688	-0.518
glycerol2	0.177	0.387
lignocerate	0.313	0.452
oleate	0.364	0.991
phosphatidylcholine	0.293	0.618
acetate	0.238	-0.066
glucAc	-0.02	0.516
Rv0950ko	0.567	1.07
Rv1096ko	1.155	1.125
Rv3684ko	0.563	0.848
delta_otsA_trehalose	-0.321	0.859