TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3327/-:

update plot	correlation	link to info on gene
Rv0797/-	(cc=0.6362)	info on Rv0797/-
Rv1360/-	(cc=0.5271)	info on Rv1360/-
Rv0577/TB27.3	(cc=0.4917)	info on Rv0577/TB27.3
Rv2701c/suhB	(cc=0.4872)	info on Rv2701c/suhB
Rv2285/-	(cc=0.4792)	info on Rv2285/-
Rv3309c/upp	(cc=0.4721)	info on Rv3309c/upp
Rv2406c/-	(cc=0.4589)	info on Rv2406c/-
Rv2615c/PE_PGRS45	(cc=0.4568)	info on Rv2615c/PE_PGRS45
Rv0747/PE_PGRS10	(cc=0.4456)	info on Rv0747/PE_PGRS10
Rv1046c/-	(cc=0.4343)	info on Rv1046c/-

Correlation of Rv3327/- with Rv0577/TB27.3

Normalized LFCs for Rv3327/-:
(description and provenance of datasets)

	Rv3327/-	Rv0577/TB27.3
Fe_supp_jason_reseq	-1.02	0.028
low_pH_jason_reseq	0.432	-0.954
NO_jason_reseq	-0.118	-0.234
B6_jason_reseq	0.114	0.242
MHCII_jason_reseq	0.012	0.772
Isoniazid02	-0.765	-0.205
Rifampicin4	-0.799	-0.758
Ethambutol3	-0.218	-0.388
Meropenem3	1.569	2.391
Vancomycin16	-0.592	-0.814
Rv2680_day32	0.044	0.888
H37Rv_KO_MarP	0.134	-0.073
hypoxia_3wks	0.49	0.231
hypoxia_6wks	0.217	0.507
glycerol	-0.307	-1.328
cholesterol	1.415	-0.523
AJ	0.407	-0.311
Bibs02	0.163	0.052
Bibs02c	0.158	-0.28
BL6	0.388	-0.564
BL6a	0.149	0.063
BXD01	-0.025	-0.157
BXD010	-0.247	-0.462
BXD011	-0.103	1.074
BXD03	-0.261	-0.496
BXD04	-0.16	-0.581
BXD05	0.437	-0.684
BXD06	-0.346	-0.343
BXD07	0.147	-0.117
BXD08	-0.32	0.197
BXD09	-0.313	0.12
CAST	0.672	-0.105
CCcont	-0.288	-0.423
DS01	0.123	0.075
DS02	0.02	0.203
DS04	0.274	-0.164
DS0c	0.24	-0.233
GP01	-0.214	-0.208
GP02	0.377	0.523
GP0c	0.555	0.164
NOD	0.159	0.098
NZO	0.264	-0.259
PWK	0.344	0.198
H37Rv_KO_CtpC	0.069	0.539
H37Rv_KO_CtpD	0.012	-0.767
H37Rv_KO_Rv1272	-0.168	0.29
H37Rv_KO_SugABC	0.732	0.703
H37Rv_KO_MbtN	-0.327	0.104
Trans05	-0.458	0.027
macrophage_unactivated	-0.391	-0.448
IL1	-0.148	-0.7
Rapamycin	-0.132	-0.767
Tcell	-0.74	-0.257
GMCSF	-0.23	0.314
IFNab	-0.738	-0.865
IFNg	-0.056	0.123
IFNg_GMCSF1	0.066	-0.094
Rv1432_day32	0.821	0.993
Rv1565c_day32	0.193	-0.673
secA2_input	-0.15	1.224
delta_Rv3594	-0.358	-0.482
delta_Rv3717	0.019	-0.171
delta_Rv3811	-0.699	-0.608
delta_Rv0954	-0.2	0.734
PonA1	0.027	0.606
EccD1_KO	0.845	1.243
EspI_KO	0.519	0.838
PE35_KO	0.551	1.21
PPE68_KO	0.48	0.253
glycerol2	-0.025	0.419
lignocerate	-0.399	0.479
oleate	0.242	0.469
phosphatidylcholine	-0.067	0.237
acetate	0.048	0.0
glucAc	-0.294	-0.129
Rv0950ko	-0.157	0.021
Rv1096ko	0.781	1.013
Rv3684ko	0.272	0.829
delta_otsA_trehalose	0.987	1.683