TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3327/-:

update plot	correlation	link to info on gene
Rv0797/-	(cc=0.6362)	info on Rv0797/-
Rv1360/-	(cc=0.5271)	info on Rv1360/-
Rv0577/TB27.3	(cc=0.4917)	info on Rv0577/TB27.3
Rv2701c/suhB	(cc=0.4872)	info on Rv2701c/suhB
Rv2285/-	(cc=0.4792)	info on Rv2285/-
Rv3309c/upp	(cc=0.4721)	info on Rv3309c/upp
Rv2406c/-	(cc=0.4589)	info on Rv2406c/-
Rv2615c/PE_PGRS45	(cc=0.4568)	info on Rv2615c/PE_PGRS45
Rv0747/PE_PGRS10	(cc=0.4456)	info on Rv0747/PE_PGRS10
Rv1046c/-	(cc=0.4343)	info on Rv1046c/-

Correlation of Rv3327/- with Rv0797/-

Normalized LFCs for Rv3327/-:
(description and provenance of datasets)

	Rv3327/-	Rv0797/-
Fe_supp_jason_reseq	-1.02	-0.488
low_pH_jason_reseq	0.432	0.877
NO_jason_reseq	-0.118	0.018
B6_jason_reseq	0.114	0.073
MHCII_jason_reseq	0.012	0.285
Isoniazid02	-0.765	0.294
Rifampicin4	-0.799	0.866
Ethambutol3	-0.218	0.522
Meropenem3	1.569	1.577
Vancomycin16	-0.592	0.748
Rv2680_day32	0.044	0.23
H37Rv_KO_MarP	0.134	-0.023
hypoxia_3wks	0.49	0.451
hypoxia_6wks	0.217	-0.119
glycerol	-0.307	-0.622
cholesterol	1.415	1.999
AJ	0.407	-0.234
Bibs02	0.163	-0.101
Bibs02c	0.158	0.452
BL6	0.388	0.784
BL6a	0.149	0.367
BXD01	-0.025	0.379
BXD010	-0.247	-0.02
BXD011	-0.103	-0.15
BXD03	-0.261	0.007
BXD04	-0.16	-0.047
BXD05	0.437	0.685
BXD06	-0.346	0.174
BXD07	0.147	0.64
BXD08	-0.32	0.102
BXD09	-0.313	0.059
CAST	0.672	0.267
CCcont	-0.288	0.316
DS01	0.123	0.406
DS02	0.02	-0.107
DS04	0.274	0.611
DS0c	0.24	-0.156
GP01	-0.214	-0.333
GP02	0.377	0.44
GP0c	0.555	-0.028
NOD	0.159	0.151
NZO	0.264	-0.189
PWK	0.344	0.264
H37Rv_KO_CtpC	0.069	0.358
H37Rv_KO_CtpD	0.012	0.079
H37Rv_KO_Rv1272	-0.168	-0.812
H37Rv_KO_SugABC	0.732	0.601
H37Rv_KO_MbtN	-0.327	-0.459
Trans05	-0.458	-0.365
macrophage_unactivated	-0.391	-0.18
IL1	-0.148	0.142
Rapamycin	-0.132	0.371
Tcell	-0.74	-0.456
GMCSF	-0.23	0.055
IFNab	-0.738	-0.444
IFNg	-0.056	0.219
IFNg_GMCSF1	0.066	0.258
Rv1432_day32	0.821	0.482
Rv1565c_day32	0.193	-0.161
secA2_input	-0.15	-0.441
delta_Rv3594	-0.358	-0.548
delta_Rv3717	0.019	0.522
delta_Rv3811	-0.699	0.192
delta_Rv0954	-0.2	0.132
PonA1	0.027	0.376
EccD1_KO	0.845	0.701
EspI_KO	0.519	1.001
PE35_KO	0.551	0.828
PPE68_KO	0.48	0.477
glycerol2	-0.025	-0.071
lignocerate	-0.399	0.06
oleate	0.242	-0.391
phosphatidylcholine	-0.067	0.008
acetate	0.048	0.605
glucAc	-0.294	0.172
Rv0950ko	-0.157	0.178
Rv1096ko	0.781	1.393
Rv3684ko	0.272	0.871
delta_otsA_trehalose	0.987	2.102