TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3110/moaB1:

update plot	correlation	link to info on gene
Rv1521/fadD25	(cc=0.5747)	info on Rv1521/fadD25
Rv1984c/cfp21	(cc=0.5337)	info on Rv1984c/cfp21
Rv1861/-	(cc=0.5186)	info on Rv1861/-
Rv2491/-	(cc=0.5125)	info on Rv2491/-
Rv3121/cyp141	(cc=0.5063)	info on Rv3121/cyp141
Rv1456c/-	(cc=0.4815)	info on Rv1456c/-
Rv1551/plsB1	(cc=0.4618)	info on Rv1551/plsB1
Rv2962c/-	(cc=0.4558)	info on Rv2962c/-
Rv1949c/-	(cc=0.4541)	info on Rv1949c/-
Rv1213/glgC	(cc=0.448)	info on Rv1213/glgC

Correlation of Rv3110/moaB1 with Rv1551/plsB1

Normalized LFCs for Rv3110/moaB1:
(description and provenance of datasets)

	Rv3110/moaB1	Rv1551/plsB1
Fe_supp_jason_reseq	1.718	0.923
low_pH_jason_reseq	-0.552	-0.266
NO_jason_reseq	0.176	-0.079
B6_jason_reseq	-0.448	-1.362
MHCII_jason_reseq	-0.669	-0.572
Isoniazid02	-0.367	-0.127
Rifampicin4	-0.929	-0.799
Ethambutol3	0.202	-0.186
Meropenem3	-0.341	0.818
Vancomycin16	0.26	-0.164
Rv2680_day32	0.495	-0.362
H37Rv_KO_MarP	0.152	-0.041
hypoxia_3wks	0.315	0.467
hypoxia_6wks	0.541	0.501
glycerol	-3.05	0.0
cholesterol	0.0	0.54
AJ	-0.227	0.471
Bibs02	-0.415	-0.216
Bibs02c	-1.141	0.077
BL6	0.483	1.452
BL6a	0.099	1.027
BXD01	-0.456	0.776
BXD010	0.36	0.664
BXD011	-0.066	1.181
BXD03	-0.555	0.654
BXD04	-0.144	1.037
BXD05	0.251	0.698
BXD06	0.044	0.992
BXD07	0.069	1.126
BXD08	-0.419	0.874
BXD09	-0.061	1.168
CAST	-1.096	-0.043
CCcont	-0.633	0.858
DS01	-0.664	0.368
DS02	-0.922	0.474
DS04	-0.503	0.846
DS0c	-0.134	0.662
GP01	1.334	1.403
GP02	-0.18	2.109
GP0c	0.808	1.501
NOD	-0.462	-0.085
NZO	-0.29	-0.114
PWK	-0.988	-0.037
H37Rv_KO_CtpC	1.258	1.161
H37Rv_KO_CtpD	2.169	0.714
H37Rv_KO_Rv1272	1.895	1.832
H37Rv_KO_SugABC	1.661	1.585
H37Rv_KO_MbtN	1.473	1.287
Trans05	0.717	1.442
macrophage_unactivated	-0.35	0.29
IL1	-0.46	0.602
Rapamycin	-0.568	1.169
Tcell	0.573	0.85
GMCSF	0.0	0.473
IFNab	0.348	0.925
IFNg	-1.016	0.786
IFNg_GMCSF1	-0.258	0.487
Rv1432_day32	-0.782	-0.587
Rv1565c_day32	0.51	0.665
secA2_input	-1.077	-0.983
delta_Rv3594	0.486	0.433
delta_Rv3717	0.023	0.371
delta_Rv3811	0.607	-0.284
delta_Rv0954	-0.119	0.366
PonA1	-0.162	0.669
EccD1_KO	0.141	0.043
EspI_KO	-0.371	0.724
PE35_KO	0.484	0.508
PPE68_KO	0.339	0.557
glycerol2	-0.132	-0.147
lignocerate	-0.132	0.035
oleate	-0.057	0.322
phosphatidylcholine	0.289	0.265
acetate	-0.399	0.095
glucAc	-0.585	-0.124
Rv0950ko	0.516	-0.356
Rv1096ko	-0.887	0.112
Rv3684ko	-0.203	0.121
delta_otsA_trehalose	0.208	0.34