TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3110/moaB1:

update plot	correlation	link to info on gene
Rv1521/fadD25	(cc=0.5747)	info on Rv1521/fadD25
Rv1984c/cfp21	(cc=0.5337)	info on Rv1984c/cfp21
Rv1861/-	(cc=0.5186)	info on Rv1861/-
Rv2491/-	(cc=0.5125)	info on Rv2491/-
Rv3121/cyp141	(cc=0.5063)	info on Rv3121/cyp141
Rv1456c/-	(cc=0.4815)	info on Rv1456c/-
Rv1551/plsB1	(cc=0.4618)	info on Rv1551/plsB1
Rv2962c/-	(cc=0.4558)	info on Rv2962c/-
Rv1949c/-	(cc=0.4541)	info on Rv1949c/-
Rv1213/glgC	(cc=0.448)	info on Rv1213/glgC

Correlation of Rv3110/moaB1 with Rv1521/fadD25

Normalized LFCs for Rv3110/moaB1:
(description and provenance of datasets)

	Rv3110/moaB1	Rv1521/fadD25
Fe_supp_jason_reseq	1.718	1.408
low_pH_jason_reseq	-0.552	-0.495
NO_jason_reseq	0.176	0.0
B6_jason_reseq	-0.448	0.444
MHCII_jason_reseq	-0.669	0.125
Isoniazid02	-0.367	-0.183
Rifampicin4	-0.929	0.133
Ethambutol3	0.202	0.322
Meropenem3	-0.341	0.081
Vancomycin16	0.26	0.379
Rv2680_day32	0.495	0.161
H37Rv_KO_MarP	0.152	0.0
hypoxia_3wks	0.315	0.698
hypoxia_6wks	0.541	0.576
glycerol	-3.05	-0.404
cholesterol	0.0	-0.35
AJ	-0.227	0.274
Bibs02	-0.415	0.539
Bibs02c	-1.141	-0.537
BL6	0.483	0.492
BL6a	0.099	0.408
BXD01	-0.456	0.906
BXD010	0.36	1.149
BXD011	-0.066	0.802
BXD03	-0.555	1.018
BXD04	-0.144	1.19
BXD05	0.251	0.952
BXD06	0.044	0.737
BXD07	0.069	0.688
BXD08	-0.419	1.121
BXD09	-0.061	0.668
CAST	-1.096	0.052
CCcont	-0.633	0.478
DS01	-0.664	0.027
DS02	-0.922	0.0
DS04	-0.503	-0.045
DS0c	-0.134	-0.05
GP01	1.334	0.634
GP02	-0.18	1.092
GP0c	0.808	0.726
NOD	-0.462	0.524
NZO	-0.29	-0.023
PWK	-0.988	-0.59
H37Rv_KO_CtpC	1.258	1.032
H37Rv_KO_CtpD	2.169	1.28
H37Rv_KO_Rv1272	1.895	1.45
H37Rv_KO_SugABC	1.661	0.767
H37Rv_KO_MbtN	1.473	1.982
Trans05	0.717	1.332
macrophage_unactivated	-0.35	0.505
IL1	-0.46	0.552
Rapamycin	-0.568	0.703
Tcell	0.573	0.404
GMCSF	0.0	0.129
IFNab	0.348	0.72
IFNg	-1.016	0.476
IFNg_GMCSF1	-0.258	0.531
Rv1432_day32	-0.782	0.169
Rv1565c_day32	0.51	0.313
secA2_input	-1.077	-0.762
delta_Rv3594	0.486	0.515
delta_Rv3717	0.023	-0.225
delta_Rv3811	0.607	0.0
delta_Rv0954	-0.119	-0.127
PonA1	-0.162	-0.18
EccD1_KO	0.141	0.033
EspI_KO	-0.371	0.314
PE35_KO	0.484	0.347
PPE68_KO	0.339	0.65
glycerol2	-0.132	-0.149
lignocerate	-0.132	-0.496
oleate	-0.057	0.067
phosphatidylcholine	0.289	-0.045
acetate	-0.399	-0.308
glucAc	-0.585	-0.773
Rv0950ko	0.516	0.193
Rv1096ko	-0.887	-1.194
Rv3684ko	-0.203	-0.793
delta_otsA_trehalose	0.208	0.144