TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3109/moaA1:

update plot	correlation	link to info on gene
Rv0830/-	(cc=0.5729)	info on Rv0830/-
Rv3514/PE_PGRS57	(cc=0.5591)	info on Rv3514/PE_PGRS57
Rv0342/iniA	(cc=0.5579)	info on Rv0342/iniA
Rv3508/PE_PGRS54	(cc=0.5395)	info on Rv3508/PE_PGRS54
Rv1488/-	(cc=0.533)	info on Rv1488/-
Rv0160c/PE4	(cc=0.5132)	info on Rv0160c/PE4
Rv3312c/-	(cc=0.4917)	info on Rv3312c/-
Rv0404/fadD30	(cc=0.4811)	info on Rv0404/fadD30
Rv2143/-	(cc=0.4807)	info on Rv2143/-
Rv0968/-	(cc=0.4799)	info on Rv0968/-

Correlation of Rv3109/moaA1 with Rv0160c/PE4

Normalized LFCs for Rv3109/moaA1:
(description and provenance of datasets)

	Rv3109/moaA1	Rv0160c/PE4
Fe_supp_jason_reseq	0.579	0.011
low_pH_jason_reseq	-1.109	-0.07
NO_jason_reseq	-0.651	-0.11
B6_jason_reseq	0.082	0.416
MHCII_jason_reseq	0.841	0.302
Isoniazid02	-1.881	-1.8
Rifampicin4	0.523	0.208
Ethambutol3	-1.529	-0.931
Meropenem3	-1.345	-1.482
Vancomycin16	-0.456	-0.836
Rv2680_day32	0.174	-0.088
H37Rv_KO_MarP	-0.648	0.748
hypoxia_3wks	0.163	-0.191
hypoxia_6wks	-0.088	-0.175
glycerol	0.0	0.471
cholesterol	-0.674	0.477
AJ	0.834	0.062
Bibs02	-0.319	0.886
Bibs02c	-0.365	0.584
BL6	-0.69	0.188
BL6a	-0.613	0.375
BXD01	-0.147	-0.029
BXD010	-0.352	-0.023
BXD011	0.0	0.241
BXD03	-0.943	0.15
BXD04	0.556	0.354
BXD05	0.17	0.048
BXD06	-0.073	0.316
BXD07	-0.702	0.182
BXD08	0.289	0.338
BXD09	-0.654	0.032
CAST	0.062	0.427
CCcont	-0.633	-0.148
DS01	-0.267	0.281
DS02	-0.837	0.584
DS04	0.697	0.126
DS0c	-0.919	-0.141
GP01	0.335	0.358
GP02	0.765	1.382
GP0c	0.035	-0.229
NOD	-0.617	0.364
NZO	0.559	0.887
PWK	-0.281	0.193
H37Rv_KO_CtpC	0.242	0.447
H37Rv_KO_CtpD	1.273	1.091
H37Rv_KO_Rv1272	1.166	1.015
H37Rv_KO_SugABC	0.171	0.612
H37Rv_KO_MbtN	0.534	0.485
Trans05	1.08	0.807
macrophage_unactivated	-0.363	-0.354
IL1	-1.818	0.098
Rapamycin	-0.945	0.239
Tcell	-0.186	-0.248
GMCSF	-1.001	-0.09
IFNab	-1.37	0.039
IFNg	-1.419	0.294
IFNg_GMCSF1	-0.361	0.085
Rv1432_day32	-0.231	0.339
Rv1565c_day32	0.952	0.458
secA2_input	0.377	-0.333
delta_Rv3594	-0.58	-0.099
delta_Rv3717	-0.826	-0.239
delta_Rv3811	-0.849	-0.223
delta_Rv0954	-0.311	0.358
PonA1	-1.287	0.126
EccD1_KO	0.49	-0.444
EspI_KO	-1.124	0.074
PE35_KO	-1.033	-0.446
PPE68_KO	-0.419	-0.221
glycerol2	0.395	0.276
lignocerate	0.0	0.284
oleate	0.259	0.216
phosphatidylcholine	0.483	0.387
acetate	0.0	0.083
glucAc	-0.216	0.264
Rv0950ko	0.537	0.479
Rv1096ko	-0.748	-0.13
Rv3684ko	0.242	0.134
delta_otsA_trehalose	1.166	0.026