TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3045/adhC:

update plot	correlation	link to info on gene
Rv3133c/devR	(cc=0.6328)	info on Rv3133c/devR
Rv3814c/-	(cc=0.6194)	info on Rv3814c/-
Rv3600c/-	(cc=0.5849)	info on Rv3600c/-
Rv1633/uvrB	(cc=0.5797)	info on Rv1633/uvrB
Rv3720/-	(cc=0.5746)	info on Rv3720/-
Rv2299c/htpG	(cc=0.5652)	info on Rv2299c/htpG
Rv3397c/phyA	(cc=0.5318)	info on Rv3397c/phyA
Rv0821c/phoY2	(cc=0.5312)	info on Rv0821c/phoY2
Rv0073/-	(cc=0.53)	info on Rv0073/-
Rv2179c/-	(cc=0.5232)	info on Rv2179c/-

Correlation of Rv3045/adhC with Rv3600c/-

Normalized LFCs for Rv3045/adhC:
(description and provenance of datasets)

	Rv3045/adhC	Rv3600c/-
Fe_supp_jason_reseq	1.118	1.077
low_pH_jason_reseq	1.246	1.623
NO_jason_reseq	-1.987	0.782
B6_jason_reseq	-0.069	1.175
MHCII_jason_reseq	-0.36	1.194
Isoniazid02	-2.177	-2.734
Rifampicin4	-0.65	-1.189
Ethambutol3	-0.829	0.083
Meropenem3	-2.737	-1.592
Vancomycin16	-2.43	0.52
Rv2680_day32	0.379	1.45
H37Rv_KO_MarP	0.629	0.794
hypoxia_3wks	-4.115	-4.135
hypoxia_6wks	-2.023	-3.773
glycerol	1.36	1.198
cholesterol	0.976	0.85
AJ	0.176	0.165
Bibs02	-0.189	0.595
Bibs02c	0.844	0.503
BL6	1.377	0.361
BL6a	0.904	0.661
BXD01	1.168	0.48
BXD010	0.752	0.046
BXD011	1.184	0.256
BXD03	1.321	-0.423
BXD04	1.514	0.158
BXD05	1.554	0.672
BXD06	1.018	0.281
BXD07	1.159	0.13
BXD08	1.052	0.433
BXD09	1.65	0.543
CAST	0.454	-0.609
CCcont	1.772	1.026
DS01	1.107	1.215
DS02	0.498	0.876
DS04	0.981	0.732
DS0c	1.07	1.163
GP01	-0.622	0.572
GP02	-0.726	0.059
GP0c	0.169	-0.1
NOD	0.652	-0.142
NZO	0.259	-0.318
PWK	-0.161	0.0
H37Rv_KO_CtpC	0.612	-1.412
H37Rv_KO_CtpD	1.994	1.936
H37Rv_KO_Rv1272	1.344	0.225
H37Rv_KO_SugABC	1.218	-1.267
H37Rv_KO_MbtN	-0.107	-0.194
Trans05	0.361	-0.476
macrophage_unactivated	2.001	1.054
IL1	-0.469	-0.819
Rapamycin	0.832	0.0
Tcell	0.463	-0.658
GMCSF	0.129	-0.533
IFNab	0.629	-0.193
IFNg	-0.497	-1.165
IFNg_GMCSF1	-0.079	-0.635
Rv1432_day32	-1.061	1.008
Rv1565c_day32	0.81	1.399
secA2_input	0.534	-0.064
delta_Rv3594	0.298	-0.101
delta_Rv3717	0.279	-0.055
delta_Rv3811	0.785	-0.628
delta_Rv0954	-0.125	-1.765
PonA1	0.172	1.348
EccD1_KO	0.217	0.171
EspI_KO	0.704	0.59
PE35_KO	-0.242	0.735
PPE68_KO	-0.176	0.627
glycerol2	0.163	-0.385
lignocerate	0.688	0.178
oleate	-0.106	-1.0
phosphatidylcholine	0.468	0.08
acetate	-0.081	0.617
glucAc	0.496	0.598
Rv0950ko	0.199	1.034
Rv1096ko	0.82	0.546
Rv3684ko	1.281	0.927
delta_otsA_trehalose	-1.408	-0.459