TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2962c/-:

update plot	correlation	link to info on gene
Rv1866/-	(cc=0.5811)	info on Rv1866/-
Rv3223c/sigH	(cc=0.5099)	info on Rv3223c/sigH
Rv3555c/-	(cc=0.4758)	info on Rv3555c/-
Rv1755c/plcD	(cc=0.4722)	info on Rv1755c/plcD
Rv1872c/lldD2	(cc=0.4636)	info on Rv1872c/lldD2
Rv1913/-	(cc=0.4592)	info on Rv1913/-
Rv3110/moaB1	(cc=0.4558)	info on Rv3110/moaB1
Rv1087/PE_PGRS21	(cc=0.4554)	info on Rv1087/PE_PGRS21
Rv2841c/nusA	(cc=0.4546)	info on Rv2841c/nusA
Rv1962A/vapB35	(cc=0.4544)	info on Rv1962A/vapB35

Correlation of Rv2962c/- with Rv3110/moaB1

Normalized LFCs for Rv2962c/-:
(description and provenance of datasets)

	Rv2962c/-	Rv3110/moaB1
Fe_supp_jason_reseq	0.655	1.718
low_pH_jason_reseq	-0.823	-0.552
NO_jason_reseq	-0.142	0.176
B6_jason_reseq	0.103	-0.448
MHCII_jason_reseq	0.459	-0.669
Isoniazid02	1.398	-0.367
Rifampicin4	-0.192	-0.929
Ethambutol3	1.025	0.202
Meropenem3	-0.193	-0.341
Vancomycin16	-0.326	0.26
Rv2680_day32	0.05	0.495
H37Rv_KO_MarP	0.586	0.152
hypoxia_3wks	0.239	0.315
hypoxia_6wks	0.056	0.541
glycerol	-0.984	-3.05
cholesterol	1.795	0.0
AJ	0.35	-0.227
Bibs02	-0.351	-0.415
Bibs02c	-0.606	-1.141
BL6	1.034	0.483
BL6a	0.026	0.099
BXD01	0.577	-0.456
BXD010	0.626	0.36
BXD011	0.111	-0.066
BXD03	0.396	-0.555
BXD04	0.461	-0.144
BXD05	0.203	0.251
BXD06	0.331	0.044
BXD07	0.504	0.069
BXD08	0.514	-0.419
BXD09	0.362	-0.061
CAST	-0.235	-1.096
CCcont	0.57	-0.633
DS01	0.248	-0.664
DS02	0.176	-0.922
DS04	-0.013	-0.503
DS0c	0.163	-0.134
GP01	0.759	1.334
GP02	1.286	-0.18
GP0c	0.698	0.808
NOD	0.732	-0.462
NZO	0.026	-0.29
PWK	0.148	-0.988
H37Rv_KO_CtpC	0.459	1.258
H37Rv_KO_CtpD	1.486	2.169
H37Rv_KO_Rv1272	0.532	1.895
H37Rv_KO_SugABC	0.535	1.661
H37Rv_KO_MbtN	1.092	1.473
Trans05	0.78	0.717
macrophage_unactivated	-0.18	-0.35
IL1	-0.878	-0.46
Rapamycin	-1.004	-0.568
Tcell	-0.583	0.573
GMCSF	-1.075	0.0
IFNab	-0.626	0.348
IFNg	-0.831	-1.016
IFNg_GMCSF1	-0.65	-0.258
Rv1432_day32	0.159	-0.782
Rv1565c_day32	0.047	0.51
secA2_input	-0.576	-1.077
delta_Rv3594	0.113	0.486
delta_Rv3717	-0.036	0.023
delta_Rv3811	0.11	0.607
delta_Rv0954	0.554	-0.119
PonA1	-0.022	-0.162
EccD1_KO	0.832	0.141
EspI_KO	-0.086	-0.371
PE35_KO	0.615	0.484
PPE68_KO	0.563	0.339
glycerol2	0.397	-0.132
lignocerate	0.189	-0.132
oleate	0.238	-0.057
phosphatidylcholine	0.321	0.289
acetate	0.268	-0.399
glucAc	0.346	-0.585
Rv0950ko	-0.169	0.516
Rv1096ko	0.229	-0.887
Rv3684ko	0.416	-0.203
delta_otsA_trehalose	1.239	0.208