TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2898c/-:

update plot	correlation	link to info on gene
Rv3411c/guaB2	(cc=0.4892)	info on Rv3411c/guaB2
Rv3696c/glpK	(cc=0.4577)	info on Rv3696c/glpK
Rv2750/-	(cc=0.4429)	info on Rv2750/-
Rv2655c/-	(cc=0.4409)	info on Rv2655c/-
Rv0526/-	(cc=0.4319)	info on Rv0526/-
Rv2169c/-	(cc=0.4306)	info on Rv2169c/-
Rv3475/-	(cc=0.4303)	info on Rv3475/-
Rv2615c/PE_PGRS45	(cc=0.4185)	info on Rv2615c/PE_PGRS45
Rv2489c/-	(cc=0.4122)	info on Rv2489c/-
Rv3187/-	(cc=0.412)	info on Rv3187/-

Correlation of Rv2898c/- with Rv0526/-

Normalized LFCs for Rv2898c/-:
(description and provenance of datasets)

	Rv2898c/-	Rv0526/-
Fe_supp_jason_reseq	-1.514	0.0
low_pH_jason_reseq	-1.066	0.0
NO_jason_reseq	-0.522	0.0
B6_jason_reseq	-1.384	0.0
MHCII_jason_reseq	0.282	0.0
Isoniazid02	-0.455	0.0
Rifampicin4	-1.668	0.0
Ethambutol3	-1.216	0.0
Meropenem3	-1.744	0.0
Vancomycin16	-1.122	0.0
Rv2680_day32	-0.947	0.0
H37Rv_KO_MarP	0.635	0.0
hypoxia_3wks	1.316	0.0
hypoxia_6wks	1.957	0.0
glycerol	0.929	0.0
cholesterol	-0.582	0.0
AJ	3.511	0.0
Bibs02	1.71	0.0
Bibs02c	-2.099	0.0
BL6	-2.023	0.0
BL6a	-0.93	0.0
BXD01	-1.384	0.0
BXD010	1.412	0.0
BXD011	0.325	0.0
BXD03	-0.5	0.0
BXD04	-0.457	0.0
BXD05	-0.061	0.0
BXD06	0.058	0.0
BXD07	-1.237	0.0
BXD08	0.649	0.0
BXD09	-0.274	0.0
CAST	0.627	0.0
CCcont	-2.416	0.0
DS01	0.152	0.0
DS02	-1.624	0.0
DS04	3.064	0.0
DS0c	0.047	0.0
GP01	-1.498	0.0
GP02	-1.346	0.0
GP0c	-1.031	0.0
NOD	0.573	0.0
NZO	3.55	0.0
PWK	6.0	0.0
H37Rv_KO_CtpC	-0.879	0.0
H37Rv_KO_CtpD	-1.701	0.0
H37Rv_KO_Rv1272	-0.032	0.0
H37Rv_KO_SugABC	-0.885	0.0
H37Rv_KO_MbtN	-1.471	0.0
Trans05	-1.654	0.0
macrophage_unactivated	-1.566	0.0
IL1	-0.765	0.0
Rapamycin	-0.697	0.0
Tcell	0.857	0.0
GMCSF	-1.946	0.0
IFNab	-0.877	0.0
IFNg	-1.326	0.0
IFNg_GMCSF1	-1.559	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	-1.829	0.0
secA2_input	1.263	-0.412
delta_Rv3594	-1.046	0.0
delta_Rv3717	0.313	0.0
delta_Rv3811	-0.351	0.205
delta_Rv0954	-0.827	0.0
PonA1	-0.511	0.0
EccD1_KO	-1.73	0.0
EspI_KO	2.236	0.0
PE35_KO	2.08	0.767
PPE68_KO	2.281	0.442
glycerol2	-2.996	-1.499
lignocerate	-1.891	-1.303
oleate	-3.031	-1.517
phosphatidylcholine	-2.801	-1.499
acetate	-3.554	-1.779
glucAc	-2.21	-1.106
Rv0950ko	-0.407	0.416
Rv1096ko	-0.407	0.0
Rv3684ko	-2.358	0.0
delta_otsA_trehalose	2.546	0.0