TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2801A/mazE9:

update plot	correlation	link to info on gene
Rv1798/eccA5	(cc=0.4252)	info on Rv1798/eccA5
Rv3645/-	(cc=0.4185)	info on Rv3645/-
Rv2614A/-	(cc=0.415)	info on Rv2614A/-
Rv3312A/-	(cc=0.4091)	info on Rv3312A/-
Rv1769/-	(cc=0.4057)	info on Rv1769/-
Rv3722c/-	(cc=0.3967)	info on Rv3722c/-
Rv3867/espH	(cc=0.3912)	info on Rv3867/espH
Rv1692/-	(cc=0.3877)	info on Rv1692/-
Rv0101/nrp	(cc=0.3798)	info on Rv0101/nrp
Rv0383c/-	(cc=0.3742)	info on Rv0383c/-

Correlation of Rv2801A/mazE9 with Rv1692/-

Normalized LFCs for Rv2801A/mazE9:
(description and provenance of datasets)

	Rv2801A/mazE9	Rv1692/-
Fe_supp_jason_reseq	0.463	1.716
low_pH_jason_reseq	3.448	2.441
NO_jason_reseq	-0.158	-1.25
B6_jason_reseq	-0.343	-0.6
MHCII_jason_reseq	0.888	0.315
Isoniazid02	0.356	0.845
Rifampicin4	0.287	0.642
Ethambutol3	0.376	-0.232
Meropenem3	2.213	1.665
Vancomycin16	0.47	0.751
Rv2680_day32	-0.202	-0.315
H37Rv_KO_MarP	0.71	-0.419
hypoxia_3wks	-0.016	-0.227
hypoxia_6wks	0.867	0.28
glycerol	1.284	0.85
cholesterol	0.743	0.659
AJ	-0.576	-0.188
Bibs02	0.205	-0.403
Bibs02c	0.299	0.174
BL6	0.083	-2.353
BL6a	0.072	-0.034
BXD01	-0.59	-1.346
BXD010	0.203	-1.21
BXD011	0.397	-0.673
BXD03	0.611	-1.336
BXD04	0.124	-1.567
BXD05	0.958	-1.034
BXD06	-0.151	-1.05
BXD07	0.121	-1.498
BXD08	-0.249	-1.174
BXD09	0.078	-1.106
CAST	-0.214	-1.942
CCcont	0.519	-0.039
DS01	-0.52	-0.236
DS02	0.813	-0.411
DS04	-0.18	0.628
DS0c	0.13	0.771
GP01	0.589	-0.69
GP02	1.215	2.275
GP0c	-0.07	-0.343
NOD	-0.057	0.727
NZO	-0.231	-0.811
PWK	-0.807	-1.064
H37Rv_KO_CtpC	0.314	-0.289
H37Rv_KO_CtpD	0.401	0.625
H37Rv_KO_Rv1272	0.079	0.226
H37Rv_KO_SugABC	-0.185	0.136
H37Rv_KO_MbtN	-1.34	-1.467
Trans05	-0.118	-0.87
macrophage_unactivated	-0.265	0.271
IL1	0.549	-0.813
Rapamycin	0.767	0.516
Tcell	-0.593	-1.411
GMCSF	0.594	0.486
IFNab	0.248	1.336
IFNg	0.706	-0.909
IFNg_GMCSF1	1.263	-1.285
Rv1432_day32	0.318	-0.498
Rv1565c_day32	-2.856	-0.747
secA2_input	1.063	0.751
delta_Rv3594	0.78	-0.661
delta_Rv3717	0.381	-2.164
delta_Rv3811	0.445	-1.411
delta_Rv0954	0.681	1.512
PonA1	0.457	1.132
EccD1_KO	-0.26	1.075
EspI_KO	-0.445	1.483
PE35_KO	-0.254	0.394
PPE68_KO	-0.547	0.256
glycerol2	0.233	-0.219
lignocerate	0.03	-0.045
oleate	-0.366	0.269
phosphatidylcholine	-0.361	-0.307
acetate	0.238	0.369
glucAc	0.484	0.34
Rv0950ko	0.546	0.208
Rv1096ko	0.814	0.139
Rv3684ko	0.18	-0.318
delta_otsA_trehalose	0.609	-1.562