TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2801A/mazE9:

update plot	correlation	link to info on gene
Rv1798/eccA5	(cc=0.4252)	info on Rv1798/eccA5
Rv3645/-	(cc=0.4185)	info on Rv3645/-
Rv2614A/-	(cc=0.415)	info on Rv2614A/-
Rv3312A/-	(cc=0.4091)	info on Rv3312A/-
Rv1769/-	(cc=0.4057)	info on Rv1769/-
Rv3722c/-	(cc=0.3967)	info on Rv3722c/-
Rv3867/espH	(cc=0.3912)	info on Rv3867/espH
Rv1692/-	(cc=0.3877)	info on Rv1692/-
Rv0101/nrp	(cc=0.3798)	info on Rv0101/nrp
Rv0383c/-	(cc=0.3742)	info on Rv0383c/-

Correlation of Rv2801A/mazE9 with Rv0383c/-

Normalized LFCs for Rv2801A/mazE9:
(description and provenance of datasets)

	Rv2801A/mazE9	Rv0383c/-
Fe_supp_jason_reseq	0.463	0.0
low_pH_jason_reseq	3.448	0.738
NO_jason_reseq	-0.158	-0.746
B6_jason_reseq	-0.343	0.214
MHCII_jason_reseq	0.888	1.051
Isoniazid02	0.356	0.496
Rifampicin4	0.287	1.497
Ethambutol3	0.376	0.59
Meropenem3	2.213	0.497
Vancomycin16	0.47	0.48
Rv2680_day32	-0.202	0.576
H37Rv_KO_MarP	0.71	1.109
hypoxia_3wks	-0.016	-0.989
hypoxia_6wks	0.867	0.23
glycerol	1.284	1.33
cholesterol	0.743	1.587
AJ	-0.576	0.713
Bibs02	0.205	-0.415
Bibs02c	0.299	1.32
BL6	0.083	-0.595
BL6a	0.072	-0.449
BXD01	-0.59	-0.911
BXD010	0.203	0.211
BXD011	0.397	-0.829
BXD03	0.611	-0.223
BXD04	0.124	-0.692
BXD05	0.958	0.192
BXD06	-0.151	-1.002
BXD07	0.121	-0.716
BXD08	-0.249	-1.398
BXD09	0.078	0.07
CAST	-0.214	0.329
CCcont	0.519	-0.203
DS01	-0.52	-0.613
DS02	0.813	0.31
DS04	-0.18	-1.56
DS0c	0.13	-0.173
GP01	0.589	-0.642
GP02	1.215	-0.999
GP0c	-0.07	0.156
NOD	-0.057	-0.734
NZO	-0.231	0.613
PWK	-0.807	-0.509
H37Rv_KO_CtpC	0.314	-0.981
H37Rv_KO_CtpD	0.401	0.436
H37Rv_KO_Rv1272	0.079	-1.693
H37Rv_KO_SugABC	-0.185	-1.362
H37Rv_KO_MbtN	-1.34	-1.083
Trans05	-0.118	-1.927
macrophage_unactivated	-0.265	-0.354
IL1	0.549	0.308
Rapamycin	0.767	0.62
Tcell	-0.593	-0.121
GMCSF	0.594	1.143
IFNab	0.248	1.466
IFNg	0.706	0.0
IFNg_GMCSF1	1.263	1.276
Rv1432_day32	0.318	0.0
Rv1565c_day32	-2.856	0.0
secA2_input	1.063	0.492
delta_Rv3594	0.78	1.199
delta_Rv3717	0.381	0.927
delta_Rv3811	0.445	2.396
delta_Rv0954	0.681	1.708
PonA1	0.457	2.331
EccD1_KO	-0.26	-1.115
EspI_KO	-0.445	-1.412
PE35_KO	-0.254	-1.741
PPE68_KO	-0.547	-1.584
glycerol2	0.233	0.0
lignocerate	0.03	0.235
oleate	-0.366	0.829
phosphatidylcholine	-0.361	0.14
acetate	0.238	2.056
glucAc	0.484	0.74
Rv0950ko	0.546	1.028
Rv1096ko	0.814	0.19
Rv3684ko	0.18	0.861
delta_otsA_trehalose	0.609	-0.147