TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2789c/fadE21:

update plot	correlation	link to info on gene
Rv3425/PPE57	(cc=0.5656)	info on Rv3425/PPE57
Rv1500/-	(cc=0.5609)	info on Rv1500/-
Rv1889c/-	(cc=0.5487)	info on Rv1889c/-
Rv3324c/moaC3	(cc=0.5208)	info on Rv3324c/moaC3
Rv3008/-	(cc=0.4982)	info on Rv3008/-
Rv0246/-	(cc=0.4961)	info on Rv0246/-
Rv3747/-	(cc=0.491)	info on Rv3747/-
Rv0459/-	(cc=0.4907)	info on Rv0459/-
Rv0354c/PPE7	(cc=0.4889)	info on Rv0354c/PPE7
Rv0371c/-	(cc=0.4808)	info on Rv0371c/-

Correlation of Rv2789c/fadE21 with Rv3747/-

Normalized LFCs for Rv2789c/fadE21:
(description and provenance of datasets)

	Rv2789c/fadE21	Rv3747/-
Fe_supp_jason_reseq	0.182	0.009
low_pH_jason_reseq	-1.134	-0.554
NO_jason_reseq	-0.788	-0.633
B6_jason_reseq	-0.752	-0.965
MHCII_jason_reseq	-0.446	-0.776
Isoniazid02	-0.096	0.848
Rifampicin4	0.087	-0.414
Ethambutol3	0.32	0.646
Meropenem3	0.662	-0.307
Vancomycin16	0.626	-0.366
Rv2680_day32	-0.554	-0.198
H37Rv_KO_MarP	0.858	0.577
hypoxia_3wks	-0.116	-0.351
hypoxia_6wks	-0.123	0.395
glycerol	-0.335	-2.738
cholesterol	0.208	-1.062
AJ	-0.072	0.487
Bibs02	-0.115	-0.38
Bibs02c	2.292	0.728
BL6	1.213	-0.121
BL6a	1.992	0.359
BXD01	1.215	-0.45
BXD010	0.967	0.033
BXD011	1.017	-0.225
BXD03	1.099	-0.15
BXD04	0.073	-0.632
BXD05	0.726	0.416
BXD06	0.645	-0.123
BXD07	0.846	-0.38
BXD08	1.224	-0.174
BXD09	1.018	-0.278
CAST	-0.382	-0.407
CCcont	1.832	0.437
DS01	1.562	0.18
DS02	1.134	0.402
DS04	0.059	-0.178
DS0c	2.641	-0.038
GP01	2.281	1.006
GP02	1.632	0.141
GP0c	1.322	0.25
NOD	2.556	0.391
NZO	-1.107	-0.301
PWK	0.332	-0.516
H37Rv_KO_CtpC	1.93	0.781
H37Rv_KO_CtpD	1.332	0.612
H37Rv_KO_Rv1272	0.084	0.084
H37Rv_KO_SugABC	-1.168	0.636
H37Rv_KO_MbtN	0.253	0.04
Trans05	0.554	0.147
macrophage_unactivated	1.509	-0.464
IL1	0.297	0.044
Rapamycin	1.114	-0.451
Tcell	0.401	-1.036
GMCSF	-0.069	0.277
IFNab	0.514	-0.411
IFNg	0.748	0.11
IFNg_GMCSF1	0.534	0.594
Rv1432_day32	0.668	-0.383
Rv1565c_day32	0.231	0.177
secA2_input	-0.571	-0.333
delta_Rv3594	-0.167	-1.149
delta_Rv3717	-0.347	-0.725
delta_Rv3811	-0.195	-0.247
delta_Rv0954	-0.027	-0.419
PonA1	-0.471	-0.222
EccD1_KO	-1.0	-0.789
EspI_KO	-1.064	-0.471
PE35_KO	-0.755	-0.685
PPE68_KO	-1.046	-0.854
glycerol2	1.379	0.946
lignocerate	1.61	1.139
oleate	0.342	-0.649
phosphatidylcholine	1.49	0.66
acetate	0.973	1.765
glucAc	1.254	0.96
Rv0950ko	0.712	0.561
Rv1096ko	-0.443	0.709
Rv3684ko	0.295	0.111
delta_otsA_trehalose	-0.965	-1.212