TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2789c/fadE21:

update plot	correlation	link to info on gene
Rv3425/PPE57	(cc=0.5656)	info on Rv3425/PPE57
Rv1500/-	(cc=0.5609)	info on Rv1500/-
Rv1889c/-	(cc=0.5487)	info on Rv1889c/-
Rv3324c/moaC3	(cc=0.5208)	info on Rv3324c/moaC3
Rv3008/-	(cc=0.4982)	info on Rv3008/-
Rv0246/-	(cc=0.4961)	info on Rv0246/-
Rv3747/-	(cc=0.491)	info on Rv3747/-
Rv0459/-	(cc=0.4907)	info on Rv0459/-
Rv0354c/PPE7	(cc=0.4889)	info on Rv0354c/PPE7
Rv0371c/-	(cc=0.4808)	info on Rv0371c/-

Correlation of Rv2789c/fadE21 with Rv1889c/-

Normalized LFCs for Rv2789c/fadE21:
(description and provenance of datasets)

	Rv2789c/fadE21	Rv1889c/-
Fe_supp_jason_reseq	0.182	-0.237
low_pH_jason_reseq	-1.134	-0.223
NO_jason_reseq	-0.788	-1.515
B6_jason_reseq	-0.752	-0.589
MHCII_jason_reseq	-0.446	-2.209
Isoniazid02	-0.096	0.201
Rifampicin4	0.087	0.298
Ethambutol3	0.32	-0.302
Meropenem3	0.662	-0.397
Vancomycin16	0.626	0.061
Rv2680_day32	-0.554	-0.119
H37Rv_KO_MarP	0.858	0.55
hypoxia_3wks	-0.116	-0.53
hypoxia_6wks	-0.123	-0.378
glycerol	-0.335	-2.319
cholesterol	0.208	-2.203
AJ	-0.072	-1.377
Bibs02	-0.115	-0.348
Bibs02c	2.292	0.174
BL6	1.213	0.792
BL6a	1.992	1.4
BXD01	1.215	0.654
BXD010	0.967	1.514
BXD011	1.017	1.527
BXD03	1.099	1.267
BXD04	0.073	-0.113
BXD05	0.726	2.079
BXD06	0.645	0.833
BXD07	0.846	0.809
BXD08	1.224	0.94
BXD09	1.018	1.286
CAST	-0.382	1.436
CCcont	1.832	1.016
DS01	1.562	0.236
DS02	1.134	0.217
DS04	0.059	-2.129
DS0c	2.641	1.435
GP01	2.281	1.731
GP02	1.632	0.069
GP0c	1.322	0.521
NOD	2.556	0.646
NZO	-1.107	-1.589
PWK	0.332	0.163
H37Rv_KO_CtpC	1.93	-1.783
H37Rv_KO_CtpD	1.332	2.528
H37Rv_KO_Rv1272	0.084	2.005
H37Rv_KO_SugABC	-1.168	-1.756
H37Rv_KO_MbtN	0.253	-0.359
Trans05	0.554	1.798
macrophage_unactivated	1.509	2.834
IL1	0.297	-0.128
Rapamycin	1.114	0.252
Tcell	0.401	-1.75
GMCSF	-0.069	0.385
IFNab	0.514	2.001
IFNg	0.748	1.449
IFNg_GMCSF1	0.534	1.159
Rv1432_day32	0.668	-1.328
Rv1565c_day32	0.231	-1.275
secA2_input	-0.571	-0.031
delta_Rv3594	-0.167	-1.632
delta_Rv3717	-0.347	-0.084
delta_Rv3811	-0.195	-0.755
delta_Rv0954	-0.027	0.226
PonA1	-0.471	-0.268
EccD1_KO	-1.0	-2.375
EspI_KO	-1.064	-0.918
PE35_KO	-0.755	-0.971
PPE68_KO	-1.046	-1.565
glycerol2	1.379	0.209
lignocerate	1.61	0.43
oleate	0.342	-0.871
phosphatidylcholine	1.49	0.078
acetate	0.973	-0.198
glucAc	1.254	0.759
Rv0950ko	0.712	0.356
Rv1096ko	-0.443	-1.285
Rv3684ko	0.295	-0.111
delta_otsA_trehalose	-0.965	-0.016