TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2789c/fadE21:

update plot	correlation	link to info on gene
Rv3425/PPE57	(cc=0.5656)	info on Rv3425/PPE57
Rv1500/-	(cc=0.5609)	info on Rv1500/-
Rv1889c/-	(cc=0.5487)	info on Rv1889c/-
Rv3324c/moaC3	(cc=0.5208)	info on Rv3324c/moaC3
Rv3008/-	(cc=0.4982)	info on Rv3008/-
Rv0246/-	(cc=0.4961)	info on Rv0246/-
Rv3747/-	(cc=0.491)	info on Rv3747/-
Rv0459/-	(cc=0.4907)	info on Rv0459/-
Rv0354c/PPE7	(cc=0.4889)	info on Rv0354c/PPE7
Rv0371c/-	(cc=0.4808)	info on Rv0371c/-

Correlation of Rv2789c/fadE21 with Rv0459/-

Normalized LFCs for Rv2789c/fadE21:
(description and provenance of datasets)

	Rv2789c/fadE21	Rv0459/-
Fe_supp_jason_reseq	0.182	0.54
low_pH_jason_reseq	-1.134	-1.715
NO_jason_reseq	-0.788	-1.179
B6_jason_reseq	-0.752	-0.677
MHCII_jason_reseq	-0.446	-0.012
Isoniazid02	-0.096	-0.515
Rifampicin4	0.087	0.834
Ethambutol3	0.32	0.058
Meropenem3	0.662	0.359
Vancomycin16	0.626	0.077
Rv2680_day32	-0.554	-3.387
H37Rv_KO_MarP	0.858	0.357
hypoxia_3wks	-0.116	-0.163
hypoxia_6wks	-0.123	0.138
glycerol	-0.335	-1.104
cholesterol	0.208	0.334
AJ	-0.072	-0.852
Bibs02	-0.115	0.159
Bibs02c	2.292	2.292
BL6	1.213	1.188
BL6a	1.992	2.02
BXD01	1.215	0.774
BXD010	0.967	1.437
BXD011	1.017	0.68
BXD03	1.099	1.023
BXD04	0.073	0.031
BXD05	0.726	0.599
BXD06	0.645	1.026
BXD07	0.846	0.231
BXD08	1.224	0.73
BXD09	1.018	0.905
CAST	-0.382	-0.385
CCcont	1.832	0.982
DS01	1.562	0.756
DS02	1.134	0.674
DS04	0.059	2.007
DS0c	2.641	0.673
GP01	2.281	0.062
GP02	1.632	0.746
GP0c	1.322	0.975
NOD	2.556	1.699
NZO	-1.107	-2.451
PWK	0.332	-0.649
H37Rv_KO_CtpC	1.93	0.625
H37Rv_KO_CtpD	1.332	1.421
H37Rv_KO_Rv1272	0.084	-0.394
H37Rv_KO_SugABC	-1.168	-0.122
H37Rv_KO_MbtN	0.253	1.201
Trans05	0.554	0.635
macrophage_unactivated	1.509	-0.032
IL1	0.297	0.943
Rapamycin	1.114	0.792
Tcell	0.401	0.231
GMCSF	-0.069	1.743
IFNab	0.514	0.245
IFNg	0.748	-0.2
IFNg_GMCSF1	0.534	0.839
Rv1432_day32	0.668	0.902
Rv1565c_day32	0.231	0.229
secA2_input	-0.571	-1.352
delta_Rv3594	-0.167	-0.58
delta_Rv3717	-0.347	-0.078
delta_Rv3811	-0.195	-1.863
delta_Rv0954	-0.027	0.186
PonA1	-0.471	0.346
EccD1_KO	-1.0	-0.358
EspI_KO	-1.064	1.05
PE35_KO	-0.755	-0.618
PPE68_KO	-1.046	-0.042
glycerol2	1.379	-0.193
lignocerate	1.61	-0.226
oleate	0.342	-0.173
phosphatidylcholine	1.49	-0.7
acetate	0.973	0.274
glucAc	1.254	0.171
Rv0950ko	0.712	-0.585
Rv1096ko	-0.443	0.145
Rv3684ko	0.295	-1.425
delta_otsA_trehalose	-0.965	1.875