TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2767c/-:

update plot	correlation	link to info on gene
Rv0231/fadE4	(cc=0.4735)	info on Rv0231/fadE4
Rv3189/-	(cc=0.452)	info on Rv3189/-
Rv1050/-	(cc=0.4485)	info on Rv1050/-
Rv1709/scpA	(cc=0.4461)	info on Rv1709/scpA
Rv2807/-	(cc=0.4358)	info on Rv2807/-
Rv0073/-	(cc=0.4331)	info on Rv0073/-
Rv1261c/-	(cc=0.4257)	info on Rv1261c/-
Rv1419/-	(cc=0.4203)	info on Rv1419/-
Rv3070/-	(cc=0.4193)	info on Rv3070/-
Rv1365c/rsfA	(cc=0.4124)	info on Rv1365c/rsfA

Correlation of Rv2767c/- with Rv1419/-

Normalized LFCs for Rv2767c/-:
(description and provenance of datasets)

	Rv2767c/-	Rv1419/-
Fe_supp_jason_reseq	0.453	-1.446
low_pH_jason_reseq	-0.731	-0.786
NO_jason_reseq	-0.302	0.538
B6_jason_reseq	-0.164	-1.016
MHCII_jason_reseq	0.028	-0.447
Isoniazid02	-0.573	-3.029
Rifampicin4	-1.384	-2.345
Ethambutol3	-1.338	-2.465
Meropenem3	-1.438	-2.318
Vancomycin16	-1.228	-2.329
Rv2680_day32	1.591	-0.265
H37Rv_KO_MarP	0.683	0.917
hypoxia_3wks	-0.136	1.304
hypoxia_6wks	-0.89	1.886
glycerol	-0.769	-0.873
cholesterol	-0.311	0.365
AJ	0.072	0.766
Bibs02	-0.23	-0.016
Bibs02c	1.449	0.106
BL6	0.825	-0.461
BL6a	1.465	0.227
BXD01	-0.782	0.789
BXD010	0.862	1.22
BXD011	0.391	0.669
BXD03	0.458	0.6
BXD04	0.09	0.17
BXD05	0.533	0.274
BXD06	0.238	1.521
BXD07	0.601	1.003
BXD08	0.009	1.444
BXD09	0.391	0.975
CAST	-0.195	0.846
CCcont	0.018	-0.411
DS01	0.332	0.481
DS02	0.488	-0.411
DS04	-0.062	-0.864
DS0c	0.888	-0.278
GP01	0.77	-1.857
GP02	0.271	-1.876
GP0c	-0.427	-1.256
NOD	0.215	0.88
NZO	0.428	0.851
PWK	0.084	0.179
H37Rv_KO_CtpC	0.685	-0.79
H37Rv_KO_CtpD	0.523	0.639
H37Rv_KO_Rv1272	0.534	1.514
H37Rv_KO_SugABC	-1.813	-2.031
H37Rv_KO_MbtN	-0.631	-0.83
Trans05	0.484	1.023
macrophage_unactivated	-0.455	-0.836
IL1	0.543	-0.406
Rapamycin	0.654	-0.611
Tcell	0.218	0.15
GMCSF	0.85	0.834
IFNab	0.381	-1.699
IFNg	0.898	0.0
IFNg_GMCSF1	0.361	-0.43
Rv1432_day32	0.51	1.883
Rv1565c_day32	0.24	1.102
secA2_input	-0.302	-1.318
delta_Rv3594	-0.277	0.788
delta_Rv3717	-0.327	-1.238
delta_Rv3811	-0.694	1.014
delta_Rv0954	0.58	0.266
PonA1	0.185	0.254
EccD1_KO	1.223	3.088
EspI_KO	1.417	0.433
PE35_KO	0.411	2.22
PPE68_KO	0.125	1.376
glycerol2	-0.835	-0.135
lignocerate	-0.432	-0.392
oleate	-0.543	0.058
phosphatidylcholine	-0.618	0.206
acetate	-0.308	0.15
glucAc	-0.141	-0.054
Rv0950ko	-0.265	1.158
Rv1096ko	0.229	1.131
Rv3684ko	0.531	2.299
delta_otsA_trehalose	-0.204	0.176