TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2767c/-:

update plot	correlation	link to info on gene
Rv0231/fadE4	(cc=0.4735)	info on Rv0231/fadE4
Rv3189/-	(cc=0.452)	info on Rv3189/-
Rv1050/-	(cc=0.4485)	info on Rv1050/-
Rv1709/scpA	(cc=0.4461)	info on Rv1709/scpA
Rv2807/-	(cc=0.4358)	info on Rv2807/-
Rv0073/-	(cc=0.4331)	info on Rv0073/-
Rv1261c/-	(cc=0.4257)	info on Rv1261c/-
Rv1419/-	(cc=0.4203)	info on Rv1419/-
Rv3070/-	(cc=0.4193)	info on Rv3070/-
Rv1365c/rsfA	(cc=0.4124)	info on Rv1365c/rsfA

Correlation of Rv2767c/- with Rv1261c/-

Normalized LFCs for Rv2767c/-:
(description and provenance of datasets)

	Rv2767c/-	Rv1261c/-
Fe_supp_jason_reseq	0.453	-0.518
low_pH_jason_reseq	-0.731	-0.601
NO_jason_reseq	-0.302	-0.231
B6_jason_reseq	-0.164	-1.692
MHCII_jason_reseq	0.028	-0.413
Isoniazid02	-0.573	-0.41
Rifampicin4	-1.384	-1.04
Ethambutol3	-1.338	-0.906
Meropenem3	-1.438	-0.46
Vancomycin16	-1.228	-0.459
Rv2680_day32	1.591	0.152
H37Rv_KO_MarP	0.683	-0.47
hypoxia_3wks	-0.136	0.0
hypoxia_6wks	-0.89	-0.883
glycerol	-0.769	1.006
cholesterol	-0.311	0.482
AJ	0.072	-0.884
Bibs02	-0.23	-1.123
Bibs02c	1.449	1.172
BL6	0.825	0.506
BL6a	1.465	1.191
BXD01	-0.782	0.46
BXD010	0.862	0.627
BXD011	0.391	0.355
BXD03	0.458	0.52
BXD04	0.09	0.303
BXD05	0.533	-0.123
BXD06	0.238	0.77
BXD07	0.601	0.751
BXD08	0.009	1.084
BXD09	0.391	0.438
CAST	-0.195	-0.649
CCcont	0.018	-0.044
DS01	0.332	0.979
DS02	0.488	0.942
DS04	-0.062	-0.822
DS0c	0.888	-0.064
GP01	0.77	-1.69
GP02	0.271	-0.955
GP0c	-0.427	-0.468
NOD	0.215	-1.051
NZO	0.428	-0.088
PWK	0.084	0.0
H37Rv_KO_CtpC	0.685	0.417
H37Rv_KO_CtpD	0.523	0.435
H37Rv_KO_Rv1272	0.534	0.137
H37Rv_KO_SugABC	-1.813	-1.494
H37Rv_KO_MbtN	-0.631	0.724
Trans05	0.484	-1.819
macrophage_unactivated	-0.455	1.086
IL1	0.543	0.368
Rapamycin	0.654	-0.049
Tcell	0.218	0.688
GMCSF	0.85	1.043
IFNab	0.381	1.481
IFNg	0.898	0.639
IFNg_GMCSF1	0.361	0.528
Rv1432_day32	0.51	-0.343
Rv1565c_day32	0.24	0.294
secA2_input	-0.302	-0.574
delta_Rv3594	-0.277	-0.075
delta_Rv3717	-0.327	-0.927
delta_Rv3811	-0.694	-1.017
delta_Rv0954	0.58	-0.063
PonA1	0.185	-0.466
EccD1_KO	1.223	0.618
EspI_KO	1.417	1.098
PE35_KO	0.411	0.0
PPE68_KO	0.125	0.544
glycerol2	-0.835	-0.75
lignocerate	-0.432	-0.414
oleate	-0.543	0.407
phosphatidylcholine	-0.618	0.265
acetate	-0.308	0.229
glucAc	-0.141	-0.666
Rv0950ko	-0.265	0.175
Rv1096ko	0.229	-0.229
Rv3684ko	0.531	0.144
delta_otsA_trehalose	-0.204	-0.881