TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2748c/ftsK:

update plot	correlation	link to info on gene
Rv0116c/ldtA	(cc=0.5142)	info on Rv0116c/ldtA
Rv3707c/-	(cc=0.5139)	info on Rv3707c/-
Rv0530/-	(cc=0.4922)	info on Rv0530/-
Rv3522/ltp4	(cc=0.4866)	info on Rv3522/ltp4
Rv1460/-	(cc=0.4509)	info on Rv1460/-
Rv1442/bisC	(cc=0.4342)	info on Rv1442/bisC
Rv3506/fadD17	(cc=0.4309)	info on Rv3506/fadD17
Rv0442c/PPE10	(cc=0.4272)	info on Rv0442c/PPE10
Rv0103c/ctpB	(cc=0.4234)	info on Rv0103c/ctpB
Rv0906/-	(cc=0.4036)	info on Rv0906/-

Correlation of Rv2748c/ftsK with Rv0116c/ldtA

Normalized LFCs for Rv2748c/ftsK:
(description and provenance of datasets)

	Rv2748c/ftsK	Rv0116c/ldtA
Fe_supp_jason_reseq	0.878	1.223
low_pH_jason_reseq	-0.303	0.542
NO_jason_reseq	-1.016	-0.953
B6_jason_reseq	0.74	-0.136
MHCII_jason_reseq	1.731	1.177
Isoniazid02	0.097	-0.944
Rifampicin4	-0.19	-0.311
Ethambutol3	0.159	-0.423
Meropenem3	0.157	0.018
Vancomycin16	1.101	-0.923
Rv2680_day32	-1.231	-0.459
H37Rv_KO_MarP	0.0	0.636
hypoxia_3wks	-0.502	0.12
hypoxia_6wks	-0.263	-0.562
glycerol	0.0	-0.74
cholesterol	0.149	-0.43
AJ	-0.173	0.329
Bibs02	0.065	0.139
Bibs02c	-0.506	-0.288
BL6	0.129	0.473
BL6a	0.07	-0.187
BXD01	0.794	0.342
BXD010	-0.975	-0.297
BXD011	-0.308	-0.519
BXD03	0.182	0.336
BXD04	-0.357	-0.304
BXD05	-0.389	-0.07
BXD06	-0.049	0.241
BXD07	0.9	0.0
BXD08	-0.322	0.044
BXD09	-0.278	0.077
CAST	0.0	0.063
CCcont	0.0	0.517
DS01	0.914	0.216
DS02	1.098	-0.314
DS04	0.135	-0.17
DS0c	1.367	-0.113
GP01	-0.195	-0.461
GP02	2.351	0.274
GP0c	0.09	-0.714
NOD	-0.257	0.57
NZO	-0.309	0.088
PWK	0.136	0.149
H37Rv_KO_CtpC	-1.808	-1.037
H37Rv_KO_CtpD	0.0	-0.32
H37Rv_KO_Rv1272	-0.105	0.114
H37Rv_KO_SugABC	1.89	0.6
H37Rv_KO_MbtN	-0.785	-0.759
Trans05	-0.995	0.514
macrophage_unactivated	0.398	0.243
IL1	0.715	0.228
Rapamycin	0.0	0.236
Tcell	1.134	0.459
GMCSF	0.919	0.903
IFNab	0.193	0.481
IFNg	0.337	0.786
IFNg_GMCSF1	1.254	0.415
Rv1432_day32	0.0	-0.106
Rv1565c_day32	0.0	-0.491
secA2_input	2.171	0.116
delta_Rv3594	-0.802	-0.312
delta_Rv3717	0.291	0.12
delta_Rv3811	-0.779	0.122
delta_Rv0954	1.485	0.018
PonA1	-0.826	0.103
EccD1_KO	-1.246	-0.72
EspI_KO	-0.328	-1.201
PE35_KO	-0.898	-1.873
PPE68_KO	-1.213	-1.565
glycerol2	0.68	-0.153
lignocerate	1.218	0.346
oleate	-0.829	-1.452
phosphatidylcholine	0.679	1.043
acetate	1.32	0.337
glucAc	1.176	0.908
Rv0950ko	0.874	0.112
Rv1096ko	0.458	0.253
Rv3684ko	1.359	0.102
delta_otsA_trehalose	0.232	-0.253