TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2536/-:

update plot	correlation	link to info on gene
Rv0174/mce1F	(cc=0.5656)	info on Rv0174/mce1F
Rv0169/mce1A	(cc=0.5413)	info on Rv0169/mce1A
Rv0176/-	(cc=0.5043)	info on Rv0176/-
Rv0173/lprK	(cc=0.5043)	info on Rv0173/lprK
Rv1490/-	(cc=0.4993)	info on Rv1490/-
Rv0505c/serB1	(cc=0.4875)	info on Rv0505c/serB1
Rv3421c/-	(cc=0.4865)	info on Rv3421c/-
Rv0175/-	(cc=0.4703)	info on Rv0175/-
Rv3419c/gcp	(cc=0.4677)	info on Rv3419c/gcp
Rv0170/mce1B	(cc=0.4565)	info on Rv0170/mce1B

Correlation of Rv2536/- with Rv1490/-

Normalized LFCs for Rv2536/-:
(description and provenance of datasets)

	Rv2536/-	Rv1490/-
Fe_supp_jason_reseq	-0.09	-0.101
low_pH_jason_reseq	-0.166	-0.683
NO_jason_reseq	1.147	0.465
B6_jason_reseq	-1.389	-1.181
MHCII_jason_reseq	-1.901	-1.175
Isoniazid02	-0.332	-0.084
Rifampicin4	1.776	0.149
Ethambutol3	0.124	0.996
Meropenem3	0.998	0.393
Vancomycin16	2.21	0.289
Rv2680_day32	-0.506	-0.698
H37Rv_KO_MarP	-1.514	0.395
hypoxia_3wks	0.367	-0.315
hypoxia_6wks	0.468	0.585
glycerol	1.393	-0.481
cholesterol	0.961	0.473
AJ	0.568	1.42
Bibs02	0.405	-0.04
Bibs02c	-1.435	-0.045
BL6	1.279	0.0
BL6a	-0.248	0.617
BXD01	0.627	-0.057
BXD010	0.774	0.738
BXD011	0.916	1.002
BXD03	0.966	0.111
BXD04	2.174	1.057
BXD05	1.31	0.561
BXD06	1.043	0.649
BXD07	1.114	0.496
BXD08	0.416	0.732
BXD09	0.786	0.843
CAST	-0.165	0.681
CCcont	0.5	0.465
DS01	-0.245	0.286
DS02	0.124	0.091
DS04	0.038	0.541
DS0c	-1.18	-0.295
GP01	-0.818	0.426
GP02	-1.542	-0.585
GP0c	-0.507	0.342
NOD	1.217	2.807
NZO	0.152	0.773
PWK	-0.793	0.899
H37Rv_KO_CtpC	0.667	-0.071
H37Rv_KO_CtpD	0.708	1.229
H37Rv_KO_Rv1272	1.673	1.771
H37Rv_KO_SugABC	2.392	1.218
H37Rv_KO_MbtN	1.121	0.851
Trans05	0.984	1.129
macrophage_unactivated	-1.6	-0.066
IL1	-0.789	0.469
Rapamycin	-0.577	-0.402
Tcell	-0.707	-0.068
GMCSF	-1.009	-0.533
IFNab	-1.427	-0.538
IFNg	-0.136	-0.056
IFNg_GMCSF1	-0.5	-0.484
Rv1432_day32	-0.875	0.033
Rv1565c_day32	-0.534	-0.269
secA2_input	-0.542	-0.823
delta_Rv3594	0.668	0.194
delta_Rv3717	0.773	0.108
delta_Rv3811	0.0	0.391
delta_Rv0954	0.266	0.585
PonA1	1.278	-0.339
EccD1_KO	0.171	-0.155
EspI_KO	0.026	-0.205
PE35_KO	0.578	0.198
PPE68_KO	0.608	0.691
glycerol2	-1.094	0.156
lignocerate	-0.268	0.462
oleate	0.299	-0.457
phosphatidylcholine	0.773	0.466
acetate	0.249	0.397
glucAc	0.462	0.585
Rv0950ko	0.461	0.066
Rv1096ko	0.335	-0.875
Rv3684ko	0.124	-0.694
delta_otsA_trehalose	-0.014	-0.9