TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2293c/-:

update plot	correlation	link to info on gene
Rv2955c/-	(cc=0.5756)	info on Rv2955c/-
Rv2270/lppN	(cc=0.5625)	info on Rv2270/lppN
Rv2083/-	(cc=0.5315)	info on Rv2083/-
Rv2021c/-	(cc=0.5227)	info on Rv2021c/-
Rv2435c/-	(cc=0.5029)	info on Rv2435c/-
Rv1869c/-	(cc=0.482)	info on Rv1869c/-
Rv1115/-	(cc=0.4722)	info on Rv1115/-
Rv2570/-	(cc=0.4634)	info on Rv2570/-
Rv3111/moaC1	(cc=0.4626)	info on Rv3111/moaC1
Rv0865/mog	(cc=0.4551)	info on Rv0865/mog

Correlation of Rv2293c/- with Rv2083/-

Normalized LFCs for Rv2293c/-:
(description and provenance of datasets)

	Rv2293c/-	Rv2083/-
Fe_supp_jason_reseq	-0.297	0.221
low_pH_jason_reseq	0.828	0.843
NO_jason_reseq	-0.425	-0.782
B6_jason_reseq	-1.388	-0.223
MHCII_jason_reseq	-0.586	0.977
Isoniazid02	-0.06	0.64
Rifampicin4	1.097	1.324
Ethambutol3	0.187	2.234
Meropenem3	2.283	0.758
Vancomycin16	0.735	0.499
Rv2680_day32	0.169	0.184
H37Rv_KO_MarP	0.979	-0.217
hypoxia_3wks	0.255	0.53
hypoxia_6wks	0.067	-0.215
glycerol	-0.582	0.613
cholesterol	-0.302	0.119
AJ	0.237	0.829
Bibs02	0.356	0.27
Bibs02c	0.956	1.643
BL6	-1.649	-0.434
BL6a	0.098	1.247
BXD01	0.147	-0.269
BXD010	-0.297	0.488
BXD011	0.031	-0.09
BXD03	-0.191	0.594
BXD04	-0.366	0.294
BXD05	0.082	0.045
BXD06	-0.227	-0.221
BXD07	-0.247	-0.458
BXD08	-0.34	0.116
BXD09	-0.169	0.365
CAST	-0.073	0.527
CCcont	-2.002	-0.817
DS01	-0.284	1.304
DS02	-0.737	0.632
DS04	-0.274	0.371
DS0c	-0.572	-0.127
GP01	0.455	0.039
GP02	-0.679	1.442
GP0c	0.14	0.378
NOD	1.404	0.574
NZO	-0.171	0.688
PWK	0.502	0.709
H37Rv_KO_CtpC	0.099	1.012
H37Rv_KO_CtpD	0.443	0.686
H37Rv_KO_Rv1272	-0.869	1.624
H37Rv_KO_SugABC	0.14	0.703
H37Rv_KO_MbtN	0.563	-0.832
Trans05	-0.138	0.935
macrophage_unactivated	0.193	0.83
IL1	-1.003	0.952
Rapamycin	-1.663	0.147
Tcell	0.039	0.137
GMCSF	0.066	0.473
IFNab	-0.233	1.052
IFNg	-0.102	1.229
IFNg_GMCSF1	0.449	0.581
Rv1432_day32	1.358	0.777
Rv1565c_day32	-1.181	0.584
secA2_input	-0.999	0.205
delta_Rv3594	0.485	0.662
delta_Rv3717	0.474	0.94
delta_Rv3811	0.248	0.956
delta_Rv0954	0.274	0.804
PonA1	-0.075	-0.882
EccD1_KO	0.638	1.184
EspI_KO	0.847	1.363
PE35_KO	1.28	0.974
PPE68_KO	1.318	0.336
glycerol2	-0.74	-0.921
lignocerate	-1.249	-1.23
oleate	0.21	-0.037
phosphatidylcholine	-0.48	-0.534
acetate	-1.599	-1.769
glucAc	-2.283	-2.327
Rv0950ko	-1.288	-0.748
Rv1096ko	-1.411	-0.679
Rv3684ko	-1.5	-1.461
delta_otsA_trehalose	0.771	1.124