TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2286c/-:

update plot	correlation	link to info on gene
Rv1662/pks8	(cc=0.5405)	info on Rv1662/pks8
Rv1964/yrbE3A	(cc=0.4348)	info on Rv1964/yrbE3A
Rv3070/-	(cc=0.4133)	info on Rv3070/-
Rv1076/lipU	(cc=0.4132)	info on Rv1076/lipU
Rv0346c/ansP2	(cc=0.4094)	info on Rv0346c/ansP2
Rv2767c/-	(cc=0.4075)	info on Rv2767c/-
Rv1557/mmpL6	(cc=0.4048)	info on Rv1557/mmpL6
Rv1980c/mpt64	(cc=0.4005)	info on Rv1980c/mpt64
Rv2558/-	(cc=0.3882)	info on Rv2558/-
Rv2231c/cobC	(cc=0.3881)	info on Rv2231c/cobC

Correlation of Rv2286c/- with Rv1557/mmpL6

Normalized LFCs for Rv2286c/-:
(description and provenance of datasets)

	Rv2286c/-	Rv1557/mmpL6
Fe_supp_jason_reseq	-0.799	-0.221
low_pH_jason_reseq	-0.052	-0.05
NO_jason_reseq	-0.081	-0.242
B6_jason_reseq	-0.688	0.354
MHCII_jason_reseq	-0.484	-0.187
Isoniazid02	-0.054	0.639
Rifampicin4	-1.007	-0.907
Ethambutol3	-0.584	-0.552
Meropenem3	-0.435	-0.582
Vancomycin16	-0.138	-0.703
Rv2680_day32	0.898	-0.355
H37Rv_KO_MarP	-0.246	0.073
hypoxia_3wks	0.096	-0.032
hypoxia_6wks	0.198	0.388
glycerol	-0.908	-0.954
cholesterol	-1.314	-0.555
AJ	0.382	0.274
Bibs02	1.003	0.452
Bibs02c	-0.182	0.049
BL6	1.322	0.043
BL6a	0.234	0.385
BXD01	-0.07	0.221
BXD010	0.431	0.03
BXD011	0.243	0.197
BXD03	0.326	0.849
BXD04	0.063	0.029
BXD05	0.042	0.412
BXD06	0.17	0.233
BXD07	0.558	0.214
BXD08	0.013	0.135
BXD09	0.699	0.173
CAST	-0.307	0.492
CCcont	0.219	0.168
DS01	-0.287	0.176
DS02	-0.397	0.279
DS04	-0.61	0.711
DS0c	0.432	0.313
GP01	1.435	0.461
GP02	-0.52	0.111
GP0c	0.092	-0.465
NOD	0.023	0.155
NZO	0.432	0.159
PWK	1.304	0.652
H37Rv_KO_CtpC	1.458	0.63
H37Rv_KO_CtpD	1.137	1.123
H37Rv_KO_Rv1272	0.954	0.917
H37Rv_KO_SugABC	-1.775	-0.055
H37Rv_KO_MbtN	0.657	0.424
Trans05	1.095	0.846
macrophage_unactivated	0.672	0.022
IL1	0.519	0.0
Rapamycin	0.654	-0.473
Tcell	0.57	-0.042
GMCSF	0.251	0.034
IFNab	0.227	-0.744
IFNg	0.086	0.224
IFNg_GMCSF1	1.2	0.123
Rv1432_day32	0.327	0.282
Rv1565c_day32	-0.493	0.742
secA2_input	0.186	-1.149
delta_Rv3594	0.959	0.84
delta_Rv3717	0.174	0.747
delta_Rv3811	1.038	0.647
delta_Rv0954	1.001	0.51
PonA1	0.613	0.0
EccD1_KO	0.431	0.145
EspI_KO	0.399	-0.131
PE35_KO	-0.117	0.254
PPE68_KO	0.243	0.25
glycerol2	0.311	0.436
lignocerate	-0.017	0.292
oleate	0.465	0.529
phosphatidylcholine	0.311	0.605
acetate	0.224	0.155
glucAc	1.153	0.104
Rv0950ko	-0.739	0.142
Rv1096ko	0.884	-0.323
Rv3684ko	-0.18	-0.55
delta_otsA_trehalose	0.648	0.165