TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2282c/-:

update plot	correlation	link to info on gene
Rv1541c/lprI	(cc=0.5791)	info on Rv1541c/lprI
Rv1052/-	(cc=0.5667)	info on Rv1052/-
Rv0914c/-	(cc=0.5661)	info on Rv0914c/-
Rv1708/-	(cc=0.5444)	info on Rv1708/-
Rv1291c/-	(cc=0.5432)	info on Rv1291c/-
Rv2515c/-	(cc=0.5427)	info on Rv2515c/-
Rv1182/papA3	(cc=0.5419)	info on Rv1182/papA3
Rv1514c/-	(cc=0.5402)	info on Rv1514c/-
Rv1250/-	(cc=0.5371)	info on Rv1250/-
Rv1251c/-	(cc=0.5223)	info on Rv1251c/-

Correlation of Rv2282c/- with Rv1514c/-

Normalized LFCs for Rv2282c/-:
(description and provenance of datasets)

	Rv2282c/-	Rv1514c/-
Fe_supp_jason_reseq	-0.358	1.347
low_pH_jason_reseq	-0.102	0.361
NO_jason_reseq	0.515	0.772
B6_jason_reseq	2.098	1.724
MHCII_jason_reseq	1.597	1.487
Isoniazid02	0.629	-0.621
Rifampicin4	0.834	-0.422
Ethambutol3	0.375	0.975
Meropenem3	0.132	-0.187
Vancomycin16	0.669	-0.414
Rv2680_day32	-0.683	-0.803
H37Rv_KO_MarP	-0.364	0.721
hypoxia_3wks	0.482	0.199
hypoxia_6wks	0.253	-0.455
glycerol	-1.336	0.989
cholesterol	-0.545	0.095
AJ	-0.632	0.432
Bibs02	-0.233	0.277
Bibs02c	0.0	0.593
BL6	-1.812	-0.088
BL6a	-0.839	-0.11
BXD01	-0.686	-0.534
BXD010	-1.313	-0.356
BXD011	-0.603	-0.354
BXD03	-1.237	-0.697
BXD04	-1.268	-0.666
BXD05	-0.661	-0.175
BXD06	-1.121	-0.602
BXD07	-0.888	-0.117
BXD08	-0.17	-0.876
BXD09	-1.249	-0.272
CAST	1.074	-0.37
CCcont	-1.715	0.079
DS01	0.467	0.094
DS02	-0.072	0.25
DS04	1.373	1.03
DS0c	-0.357	0.379
GP01	-0.673	0.014
GP02	-1.614	-1.422
GP0c	-1.493	-0.924
NOD	0.711	0.542
NZO	-0.718	-0.199
PWK	0.021	-0.054
H37Rv_KO_CtpC	-0.353	-1.154
H37Rv_KO_CtpD	-1.414	0.067
H37Rv_KO_Rv1272	0.329	-0.759
H37Rv_KO_SugABC	-1.574	0.077
H37Rv_KO_MbtN	-1.999	-0.465
Trans05	-0.811	0.243
macrophage_unactivated	-0.35	-0.486
IL1	-0.593	0.525
Rapamycin	-2.179	0.187
Tcell	-0.176	-0.209
GMCSF	0.647	-0.795
IFNab	-0.795	-0.193
IFNg	-0.374	0.569
IFNg_GMCSF1	-0.258	0.377
Rv1432_day32	-0.164	-0.902
Rv1565c_day32	0.924	0.223
secA2_input	-2.677	-1.154
delta_Rv3594	0.205	1.244
delta_Rv3717	-0.287	0.048
delta_Rv3811	-0.164	0.73
delta_Rv0954	-0.349	0.049
PonA1	0.192	0.629
EccD1_KO	0.595	1.394
EspI_KO	0.973	2.145
PE35_KO	2.395	1.852
PPE68_KO	2.265	2.755
glycerol2	-0.731	0.593
lignocerate	-0.13	0.675
oleate	-0.074	0.465
phosphatidylcholine	-0.354	0.28
acetate	0.394	0.504
glucAc	0.103	0.811
Rv0950ko	-1.188	-1.182
Rv1096ko	0.856	-0.609
Rv3684ko	0.298	-0.534
delta_otsA_trehalose	-1.239	-0.139