TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2274A/mazE8:

update plot	correlation	link to info on gene
Rv2275/-	(cc=0.7556)	info on Rv2275/-
Rv0845/-	(cc=0.5504)	info on Rv0845/-
Rv1397c/vapC10	(cc=0.5373)	info on Rv1397c/vapC10
Rv2137c/-	(cc=0.5213)	info on Rv2137c/-
Rv3398c/idsA1	(cc=0.5212)	info on Rv3398c/idsA1
Rv1729c/-	(cc=0.5188)	info on Rv1729c/-
Rv1507c/-	(cc=0.5139)	info on Rv1507c/-
Rv1521/fadD25	(cc=0.4752)	info on Rv1521/fadD25
Rv2496c/bkdB	(cc=0.4711)	info on Rv2496c/bkdB
Rv2527/vapC17	(cc=0.4648)	info on Rv2527/vapC17

Correlation of Rv2274A/mazE8 with Rv2527/vapC17

Normalized LFCs for Rv2274A/mazE8:
(description and provenance of datasets)

	Rv2274A/mazE8	Rv2527/vapC17
Fe_supp_jason_reseq	-1.073	0.923
low_pH_jason_reseq	0.408	0.758
NO_jason_reseq	0.457	0.089
B6_jason_reseq	-0.58	-0.707
MHCII_jason_reseq	-0.18	0.526
Isoniazid02	0.377	0.195
Rifampicin4	1.083	-0.027
Ethambutol3	0.043	-0.126
Meropenem3	0.238	-0.286
Vancomycin16	0.581	0.52
Rv2680_day32	0.359	0.78
H37Rv_KO_MarP	0.26	0.0
hypoxia_3wks	-0.048	-0.096
hypoxia_6wks	0.048	0.219
glycerol	-1.419	-0.373
cholesterol	-1.219	-0.822
AJ	0.382	-0.719
Bibs02	2.072	0.955
Bibs02c	-2.099	-1.458
BL6	0.275	1.226
BL6a	0.765	0.405
BXD01	1.466	1.132
BXD010	0.109	0.154
BXD011	1.765	1.138
BXD03	0.769	0.718
BXD04	0.811	0.824
BXD05	1.881	1.311
BXD06	0.952	0.797
BXD07	1.15	1.032
BXD08	2.183	1.115
BXD09	1.695	1.159
CAST	-1.246	0.305
CCcont	0.729	1.421
DS01	1.018	0.768
DS02	1.827	0.176
DS04	1.668	0.929
DS0c	0.591	1.095
GP01	-0.935	-0.584
GP02	-1.187	-0.979
GP0c	-0.61	0.381
NOD	-0.903	-0.34
NZO	0.543	0.082
PWK	-2.342	-0.465
H37Rv_KO_CtpC	1.727	0.806
H37Rv_KO_CtpD	0.769	1.658
H37Rv_KO_Rv1272	2.315	0.571
H37Rv_KO_SugABC	3.786	0.879
H37Rv_KO_MbtN	2.954	-0.747
Trans05	1.811	0.749
macrophage_unactivated	1.398	1.042
IL1	1.353	0.362
Rapamycin	2.157	0.304
Tcell	1.743	1.544
GMCSF	1.888	0.977
IFNab	0.426	-0.079
IFNg	0.997	-1.008
IFNg_GMCSF1	-0.556	0.236
Rv1432_day32	-0.426	0.07
Rv1565c_day32	-0.382	0.046
secA2_input	-1.035	-0.103
delta_Rv3594	-1.263	1.221
delta_Rv3717	-1.195	0.656
delta_Rv3811	-1.88	-0.062
delta_Rv0954	-1.616	-0.638
PonA1	-1.255	-0.126
EccD1_KO	1.756	0.77
EspI_KO	0.228	0.388
PE35_KO	0.563	1.269
PPE68_KO	1.126	1.238
glycerol2	-0.076	0.787
lignocerate	-0.359	1.08
oleate	-0.227	0.564
phosphatidylcholine	0.426	0.64
acetate	-0.474	0.815
glucAc	-0.524	0.997
Rv0950ko	-0.1	1.128
Rv1096ko	0.253	0.157
Rv3684ko	0.409	0.802
delta_otsA_trehalose	-1.615	0.051