TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2274A/mazE8:

update plot	correlation	link to info on gene
Rv2275/-	(cc=0.7556)	info on Rv2275/-
Rv0845/-	(cc=0.5504)	info on Rv0845/-
Rv1397c/vapC10	(cc=0.5373)	info on Rv1397c/vapC10
Rv2137c/-	(cc=0.5213)	info on Rv2137c/-
Rv3398c/idsA1	(cc=0.5212)	info on Rv3398c/idsA1
Rv1729c/-	(cc=0.5188)	info on Rv1729c/-
Rv1507c/-	(cc=0.5139)	info on Rv1507c/-
Rv1521/fadD25	(cc=0.4752)	info on Rv1521/fadD25
Rv2496c/bkdB	(cc=0.4711)	info on Rv2496c/bkdB
Rv2527/vapC17	(cc=0.4648)	info on Rv2527/vapC17

Correlation of Rv2274A/mazE8 with Rv1507c/-

Normalized LFCs for Rv2274A/mazE8:
(description and provenance of datasets)

	Rv2274A/mazE8	Rv1507c/-
Fe_supp_jason_reseq	-1.073	-0.712
low_pH_jason_reseq	0.408	0.795
NO_jason_reseq	0.457	-0.709
B6_jason_reseq	-0.58	-0.5
MHCII_jason_reseq	-0.18	-0.815
Isoniazid02	0.377	0.14
Rifampicin4	1.083	0.734
Ethambutol3	0.043	0.564
Meropenem3	0.238	0.274
Vancomycin16	0.581	0.828
Rv2680_day32	0.359	0.0
H37Rv_KO_MarP	0.26	-0.157
hypoxia_3wks	-0.048	0.79
hypoxia_6wks	0.048	0.637
glycerol	-1.419	-0.607
cholesterol	-1.219	-0.773
AJ	0.382	1.287
Bibs02	2.072	0.348
Bibs02c	-2.099	-0.112
BL6	0.275	-0.138
BL6a	0.765	1.329
BXD01	1.466	0.458
BXD010	0.109	0.244
BXD011	1.765	0.666
BXD03	0.769	1.115
BXD04	0.811	0.434
BXD05	1.881	1.448
BXD06	0.952	1.131
BXD07	1.15	1.267
BXD08	2.183	0.778
BXD09	1.695	1.346
CAST	-1.246	-0.39
CCcont	0.729	0.733
DS01	1.018	0.346
DS02	1.827	0.11
DS04	1.668	-0.104
DS0c	0.591	0.317
GP01	-0.935	0.837
GP02	-1.187	-0.25
GP0c	-0.61	0.76
NOD	-0.903	0.329
NZO	0.543	-0.22
PWK	-2.342	0.374
H37Rv_KO_CtpC	1.727	1.655
H37Rv_KO_CtpD	0.769	2.232
H37Rv_KO_Rv1272	2.315	0.946
H37Rv_KO_SugABC	3.786	2.191
H37Rv_KO_MbtN	2.954	0.799
Trans05	1.811	1.251
macrophage_unactivated	1.398	-0.092
IL1	1.353	0.4
Rapamycin	2.157	0.571
Tcell	1.743	0.179
GMCSF	1.888	-0.077
IFNab	0.426	-0.088
IFNg	0.997	0.147
IFNg_GMCSF1	-0.556	-0.273
Rv1432_day32	-0.426	0.662
Rv1565c_day32	-0.382	0.0
secA2_input	-1.035	-1.021
delta_Rv3594	-1.263	0.34
delta_Rv3717	-1.195	-0.405
delta_Rv3811	-1.88	-0.665
delta_Rv0954	-1.616	-0.34
PonA1	-1.255	0.054
EccD1_KO	1.756	0.171
EspI_KO	0.228	0.95
PE35_KO	0.563	0.152
PPE68_KO	1.126	0.0
glycerol2	-0.076	-0.38
lignocerate	-0.359	-0.213
oleate	-0.227	-0.315
phosphatidylcholine	0.426	0.0
acetate	-0.474	-0.904
glucAc	-0.524	-0.229
Rv0950ko	-0.1	0.513
Rv1096ko	0.253	-0.739
Rv3684ko	0.409	-0.802
delta_otsA_trehalose	-1.615	0.711