TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2177c/-:

update plot	correlation	link to info on gene
Rv2424c/-	(cc=0.5495)	info on Rv2424c/-
Rv1263/amiB2	(cc=0.5175)	info on Rv1263/amiB2
Rv2786c/ribF	(cc=0.5033)	info on Rv2786c/ribF
Rv1527c/pks5	(cc=0.4975)	info on Rv1527c/pks5
Rv1531/-	(cc=0.4577)	info on Rv1531/-
Rv0359/-	(cc=0.4498)	info on Rv0359/-
Rv3691/-	(cc=0.4479)	info on Rv3691/-
Rv1004c/-	(cc=0.4475)	info on Rv1004c/-
Rv2016/-	(cc=0.4425)	info on Rv2016/-
Rv2464c/-	(cc=0.4376)	info on Rv2464c/-

Correlation of Rv2177c/- with Rv1004c/-

Normalized LFCs for Rv2177c/-:
(description and provenance of datasets)

	Rv2177c/-	Rv1004c/-
Fe_supp_jason_reseq	0.011	-0.445
low_pH_jason_reseq	-1.226	-0.674
NO_jason_reseq	0.302	0.039
B6_jason_reseq	0.386	-0.394
MHCII_jason_reseq	-0.305	0.324
Isoniazid02	-0.054	-0.093
Rifampicin4	1.162	0.165
Ethambutol3	0.672	1.51
Meropenem3	0.639	0.527
Vancomycin16	0.504	0.379
Rv2680_day32	-0.169	0.138
H37Rv_KO_MarP	-0.174	0.33
hypoxia_3wks	0.271	0.279
hypoxia_6wks	0.336	-0.39
glycerol	-0.312	0.714
cholesterol	-0.143	0.292
AJ	0.948	0.81
Bibs02	-0.38	0.138
Bibs02c	-0.394	0.493
BL6	-0.158	-1.506
BL6a	-0.205	-0.036
BXD01	-0.61	-0.184
BXD010	-0.632	-0.421
BXD011	-0.555	-0.985
BXD03	-0.386	-0.423
BXD04	-0.057	0.212
BXD05	-0.039	-0.41
BXD06	-0.068	-0.718
BXD07	-0.227	-0.274
BXD08	-0.352	0.151
BXD09	0.067	-1.141
CAST	0.494	-0.232
CCcont	-0.651	-1.537
DS01	0.417	0.429
DS02	0.384	0.35
DS04	1.362	1.043
DS0c	-0.506	-0.162
GP01	1.28	0.82
GP02	0.324	0.257
GP0c	1.16	0.349
NOD	-0.028	0.013
NZO	0.88	-0.863
PWK	0.861	-0.402
H37Rv_KO_CtpC	-0.189	0.048
H37Rv_KO_CtpD	-0.601	0.852
H37Rv_KO_Rv1272	0.397	0.042
H37Rv_KO_SugABC	0.481	-0.087
H37Rv_KO_MbtN	-1.489	-0.348
Trans05	1.047	0.422
macrophage_unactivated	-0.887	-1.032
IL1	-0.736	-0.584
Rapamycin	-0.126	-1.132
Tcell	-0.365	-0.935
GMCSF	0.29	-1.048
IFNab	-0.538	-1.56
IFNg	-0.997	-1.636
IFNg_GMCSF1	-0.352	-1.477
Rv1432_day32	0.245	0.799
Rv1565c_day32	-0.283	-0.725
secA2_input	1.116	-0.584
delta_Rv3594	-0.433	-0.119
delta_Rv3717	-0.233	0.165
delta_Rv3811	-0.312	0.235
delta_Rv0954	-0.59	0.019
PonA1	-0.087	-0.166
EccD1_KO	-0.253	-0.125
EspI_KO	0.225	-0.054
PE35_KO	-0.761	-1.205
PPE68_KO	-0.646	-1.376
glycerol2	-0.017	-0.448
lignocerate	-0.029	-0.492
oleate	0.301	0.539
phosphatidylcholine	0.283	0.09
acetate	0.735	-0.637
glucAc	0.176	-0.92
Rv0950ko	-0.19	-0.121
Rv1096ko	-0.166	-0.072
Rv3684ko	-0.449	-0.897
delta_otsA_trehalose	-0.662	-0.838