TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2177c/-:

update plot	correlation	link to info on gene
Rv2424c/-	(cc=0.5495)	info on Rv2424c/-
Rv1263/amiB2	(cc=0.5175)	info on Rv1263/amiB2
Rv2786c/ribF	(cc=0.5033)	info on Rv2786c/ribF
Rv1527c/pks5	(cc=0.4975)	info on Rv1527c/pks5
Rv1531/-	(cc=0.4577)	info on Rv1531/-
Rv0359/-	(cc=0.4498)	info on Rv0359/-
Rv3691/-	(cc=0.4479)	info on Rv3691/-
Rv1004c/-	(cc=0.4475)	info on Rv1004c/-
Rv2016/-	(cc=0.4425)	info on Rv2016/-
Rv2464c/-	(cc=0.4376)	info on Rv2464c/-

Correlation of Rv2177c/- with Rv0359/-

Normalized LFCs for Rv2177c/-:
(description and provenance of datasets)

	Rv2177c/-	Rv0359/-
Fe_supp_jason_reseq	0.011	0.095
low_pH_jason_reseq	-1.226	-1.012
NO_jason_reseq	0.302	0.837
B6_jason_reseq	0.386	0.692
MHCII_jason_reseq	-0.305	1.3
Isoniazid02	-0.054	0.764
Rifampicin4	1.162	0.097
Ethambutol3	0.672	0.086
Meropenem3	0.639	0.109
Vancomycin16	0.504	-0.17
Rv2680_day32	-0.169	-0.023
H37Rv_KO_MarP	-0.174	0.272
hypoxia_3wks	0.271	-0.12
hypoxia_6wks	0.336	-0.079
glycerol	-0.312	0.453
cholesterol	-0.143	-0.176
AJ	0.948	0.363
Bibs02	-0.38	0.277
Bibs02c	-0.394	0.053
BL6	-0.158	-0.976
BL6a	-0.205	-0.726
BXD01	-0.61	-0.705
BXD010	-0.632	-0.867
BXD011	-0.555	-0.706
BXD03	-0.386	-1.073
BXD04	-0.057	-1.555
BXD05	-0.039	-1.302
BXD06	-0.068	-1.334
BXD07	-0.227	-1.084
BXD08	-0.352	-1.029
BXD09	0.067	-1.134
CAST	0.494	0.657
CCcont	-0.651	-1.909
DS01	0.417	0.53
DS02	0.384	0.485
DS04	1.362	0.111
DS0c	-0.506	0.528
GP01	1.28	0.353
GP02	0.324	0.863
GP0c	1.16	-0.377
NOD	-0.028	0.135
NZO	0.88	0.097
PWK	0.861	0.115
H37Rv_KO_CtpC	-0.189	-1.181
H37Rv_KO_CtpD	-0.601	-0.874
H37Rv_KO_Rv1272	0.397	-1.584
H37Rv_KO_SugABC	0.481	-0.397
H37Rv_KO_MbtN	-1.489	-0.62
Trans05	1.047	-0.053
macrophage_unactivated	-0.887	-2.093
IL1	-0.736	-1.848
Rapamycin	-0.126	-1.393
Tcell	-0.365	-1.092
GMCSF	0.29	-1.09
IFNab	-0.538	-2.053
IFNg	-0.997	-1.05
IFNg_GMCSF1	-0.352	-0.594
Rv1432_day32	0.245	0.786
Rv1565c_day32	-0.283	-0.547
secA2_input	1.116	0.38
delta_Rv3594	-0.433	-1.115
delta_Rv3717	-0.233	0.013
delta_Rv3811	-0.312	-1.166
delta_Rv0954	-0.59	-0.841
PonA1	-0.087	-0.262
EccD1_KO	-0.253	0.062
EspI_KO	0.225	0.054
PE35_KO	-0.761	-0.747
PPE68_KO	-0.646	-0.982
glycerol2	-0.017	-0.053
lignocerate	-0.029	-0.349
oleate	0.301	0.023
phosphatidylcholine	0.283	-0.038
acetate	0.735	-0.72
glucAc	0.176	-0.134
Rv0950ko	-0.19	0.597
Rv1096ko	-0.166	0.881
Rv3684ko	-0.449	0.648
delta_otsA_trehalose	-0.662	-2.016