TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2177c/-:

update plot	correlation	link to info on gene
Rv2424c/-	(cc=0.5495)	info on Rv2424c/-
Rv1263/amiB2	(cc=0.5175)	info on Rv1263/amiB2
Rv2786c/ribF	(cc=0.5033)	info on Rv2786c/ribF
Rv1527c/pks5	(cc=0.4975)	info on Rv1527c/pks5
Rv1531/-	(cc=0.4577)	info on Rv1531/-
Rv0359/-	(cc=0.4498)	info on Rv0359/-
Rv3691/-	(cc=0.4479)	info on Rv3691/-
Rv1004c/-	(cc=0.4475)	info on Rv1004c/-
Rv2016/-	(cc=0.4425)	info on Rv2016/-
Rv2464c/-	(cc=0.4376)	info on Rv2464c/-

Correlation of Rv2177c/- with Rv2424c/-

Normalized LFCs for Rv2177c/-:
(description and provenance of datasets)

	Rv2177c/-	Rv2424c/-
Fe_supp_jason_reseq	0.011	-0.701
low_pH_jason_reseq	-1.226	-1.082
NO_jason_reseq	0.302	0.349
B6_jason_reseq	0.386	0.996
MHCII_jason_reseq	-0.305	-0.668
Isoniazid02	-0.054	-0.18
Rifampicin4	1.162	0.875
Ethambutol3	0.672	0.573
Meropenem3	0.639	0.659
Vancomycin16	0.504	0.645
Rv2680_day32	-0.169	0.043
H37Rv_KO_MarP	-0.174	0.676
hypoxia_3wks	0.271	-0.167
hypoxia_6wks	0.336	0.121
glycerol	-0.312	-1.287
cholesterol	-0.143	-0.457
AJ	0.948	0.913
Bibs02	-0.38	-0.148
Bibs02c	-0.394	0.196
BL6	-0.158	0.455
BL6a	-0.205	-0.29
BXD01	-0.61	-0.276
BXD010	-0.632	-0.559
BXD011	-0.555	-0.513
BXD03	-0.386	-0.213
BXD04	-0.057	0.063
BXD05	-0.039	-0.628
BXD06	-0.068	-0.469
BXD07	-0.227	-0.288
BXD08	-0.352	-0.209
BXD09	0.067	-0.242
CAST	0.494	0.295
CCcont	-0.651	-1.203
DS01	0.417	0.33
DS02	0.384	0.775
DS04	1.362	0.864
DS0c	-0.506	0.412
GP01	1.28	0.121
GP02	0.324	0.333
GP0c	1.16	0.623
NOD	-0.028	0.413
NZO	0.88	0.909
PWK	0.861	0.645
H37Rv_KO_CtpC	-0.189	-0.184
H37Rv_KO_CtpD	-0.601	-0.777
H37Rv_KO_Rv1272	0.397	-0.222
H37Rv_KO_SugABC	0.481	-0.344
H37Rv_KO_MbtN	-1.489	-1.569
Trans05	1.047	1.084
macrophage_unactivated	-0.887	-0.407
IL1	-0.736	-1.1
Rapamycin	-0.126	-0.93
Tcell	-0.365	-0.479
GMCSF	0.29	0.098
IFNab	-0.538	-0.937
IFNg	-0.997	-0.69
IFNg_GMCSF1	-0.352	0.148
Rv1432_day32	0.245	-0.03
Rv1565c_day32	-0.283	0.215
secA2_input	1.116	0.941
delta_Rv3594	-0.433	-0.72
delta_Rv3717	-0.233	-0.865
delta_Rv3811	-0.312	-0.769
delta_Rv0954	-0.59	-1.039
PonA1	-0.087	-0.256
EccD1_KO	-0.253	2.559
EspI_KO	0.225	1.657
PE35_KO	-0.761	1.173
PPE68_KO	-0.646	1.654
glycerol2	-0.017	0.184
lignocerate	-0.029	0.183
oleate	0.301	0.604
phosphatidylcholine	0.283	0.794
acetate	0.735	0.357
glucAc	0.176	-0.149
Rv0950ko	-0.19	-0.069
Rv1096ko	-0.166	-0.187
Rv3684ko	-0.449	-0.334
delta_otsA_trehalose	-0.662	-0.098