TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1991A/mazE6:

update plot	correlation	link to info on gene
Rv1565c/-	(cc=0.5028)	info on Rv1565c/-
Rv3875/esxA	(cc=0.4993)	info on Rv3875/esxA
Rv1583c/-	(cc=0.4939)	info on Rv1583c/-
Rv0489/gpm1	(cc=0.4938)	info on Rv0489/gpm1
Rv2960c/-	(cc=0.4619)	info on Rv2960c/-
Rv1498A/-	(cc=0.4498)	info on Rv1498A/-
Rv2680/-	(cc=0.447)	info on Rv2680/-
Rv2374c/hrcA	(cc=0.445)	info on Rv2374c/hrcA
Rv1561/vapC11	(cc=0.4388)	info on Rv1561/vapC11
Rv1896c/-	(cc=0.4329)	info on Rv1896c/-

Correlation of Rv1991A/mazE6 with Rv1498A/-

Normalized LFCs for Rv1991A/mazE6:
(description and provenance of datasets)

	Rv1991A/mazE6	Rv1498A/-
Fe_supp_jason_reseq	3.195	0.684
low_pH_jason_reseq	0.694	0.0
NO_jason_reseq	-0.541	0.48
B6_jason_reseq	-0.111	-1.941
MHCII_jason_reseq	-0.572	-1.531
Isoniazid02	0.314	0.15
Rifampicin4	0.69	0.474
Ethambutol3	2.83	0.409
Meropenem3	0.756	0.21
Vancomycin16	0.626	0.515
Rv2680_day32	0.393	0.973
H37Rv_KO_MarP	-0.744	-0.418
hypoxia_3wks	-0.486	-0.299
hypoxia_6wks	-0.839	0.015
glycerol	0.709	-0.159
cholesterol	-0.159	-0.348
AJ	-1.044	-1.805
Bibs02	-0.823	-0.91
Bibs02c	-0.112	-0.133
BL6	1.907	0.571
BL6a	0.839	0.56
BXD01	0.506	-0.669
BXD010	1.024	0.357
BXD011	1.548	0.505
BXD03	0.831	0.198
BXD04	0.063	-0.866
BXD05	0.57	0.76
BXD06	0.82	-0.085
BXD07	0.434	0.513
BXD08	0.856	0.116
BXD09	0.822	0.448
CAST	-0.859	-0.472
CCcont	1.741	-0.341
DS01	1.16	-0.351
DS02	-1.161	0.101
DS04	1.015	-0.753
DS0c	-0.976	-2.861
GP01	0.925	0.436
GP02	0.511	-0.236
GP0c	2.692	0.528
NOD	1.103	-1.681
NZO	-0.744	0.139
PWK	0.196	-0.709
H37Rv_KO_CtpC	0.998	1.027
H37Rv_KO_CtpD	1.213	2.402
H37Rv_KO_Rv1272	-0.424	0.64
H37Rv_KO_SugABC	1.602	0.644
H37Rv_KO_MbtN	0.965	-0.596
Trans05	1.43	1.133
macrophage_unactivated	-1.846	-0.83
IL1	0.0	-0.323
Rapamycin	0.227	-0.319
Tcell	-0.43	-1.401
GMCSF	0.259	-0.227
IFNab	-1.031	-0.78
IFNg	0.0	-0.433
IFNg_GMCSF1	0.732	-1.775
Rv1432_day32	0.0	0.374
Rv1565c_day32	0.0	1.031
secA2_input	-2.195	-2.661
delta_Rv3594	0.895	-0.28
delta_Rv3717	0.429	-0.634
delta_Rv3811	0.617	0.326
delta_Rv0954	2.719	-0.315
PonA1	-1.829	-1.297
EccD1_KO	0.483	-1.342
EspI_KO	-0.81	-1.03
PE35_KO	-0.23	0.613
PPE68_KO	2.24	-0.787
glycerol2	1.09	-1.956
lignocerate	0.235	-0.912
oleate	-1.517	-1.062
phosphatidylcholine	0.508	-0.825
acetate	1.774	0.239
glucAc	1.515	-0.19
Rv0950ko	0.072	-0.745
Rv1096ko	-0.793	-1.535
Rv3684ko	-0.327	-2.161
delta_otsA_trehalose	0.369	-0.792